Breast cancer in men: Aspects of familial aggregation

Karin A. Rosenblatt, David B. Thomas, Anne Mctiernan, Melissa A. Austin, Helge Stalsberg, Annette Stemhagen, W. Douglas Thompson, Mary G.Mccrea Curnen, William Satariano, Donald F. Austin, Peter Isacson, Raymond S. Greenberg, Charles Key, Laurence Kolonel, Dee West

Research output: Contribution to journalArticlepeer-review

109 Scopus citations


Familial aggregation of breast cancer in males was investigated in a population-based case-control study. Cases were ascertained from 10 Surveillance, Epidemiology, and End Results Program registries in the United States between 1983 and 1986. Controls were identified by random-digit dialing and from lists of Medicare recipients. The relative odds of developing breast cancer were similar in men with affected paternal and maternal relatives and in men with affected mothers and sisters. The risk increased with the number of affected relatives. The relative odds of developing breast cancer were greater in men with first-degree relatives who developed their mammary neoplasm before the age of 45 than in men with older first-degree affected relatives; the enhancement of risk in men with an affected sister was greater in those under age 60 than in older men. These results are similar to those observed by others in studies of breast cancer in women. [J Natl Cancer Inst 83:849-854, 1991].

Original languageEnglish (US)
Pages (from-to)849-854
Number of pages6
JournalJournal of the National Cancer Institute
Issue number12
StatePublished - Jun 19 1991
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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