Breaking the mold: structures of the RNA polymerase I transcription complex reveal a new path for initiation

Ashleigh J. Jackobel; Yan Han; Yuan He; Bruce A. Knutson

doi:10.1080/21541264.2017.1416268

Breaking the mold: structures of the RNA polymerase I transcription complex reveal a new path for initiation

Ashleigh J. Jackobel, Yan Han, Yuan He, Bruce A. Knutson

Research output: Contribution to journal › Comment/debate › peer-review

4 Scopus citations

Abstract

While structures of the RNA polymerase (Pol) II initiation complex have been resolved and extensively studied, the Pol I initiation complex remained elusive. Here, we review the recent structural analyses of the yeast Pol I transcription initiation complex that reveal several unique and unexpected Pol I-specific properties.

Original language	English (US)
Pages (from-to)	255-261
Number of pages	7
Journal	Transcription
Volume	9
Issue number	4
DOIs	https://doi.org/10.1080/21541264.2017.1416268
State	Published - Aug 8 2018
Externally published	Yes

Keywords

Core Factor
RNA polymerase I
pre-initiation complex
promoter opening
promoter recognition
transcription initiation

ASJC Scopus subject areas

Biotechnology
Biochemistry
Genetics

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10.1080/21541264.2017.1416268

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title = "Breaking the mold: structures of the RNA polymerase I transcription complex reveal a new path for initiation",

abstract = "While structures of the RNA polymerase (Pol) II initiation complex have been resolved and extensively studied, the Pol I initiation complex remained elusive. Here, we review the recent structural analyses of the yeast Pol I transcription initiation complex that reveal several unique and unexpected Pol I-specific properties.",

keywords = "Core Factor, RNA polymerase I, pre-initiation complex, promoter opening, promoter recognition, transcription initiation",

author = "Jackobel, {Ashleigh J.} and Yan Han and Yuan He and Knutson, {Bruce A.}",

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AU - Jackobel, Ashleigh J.

AU - Han, Yan

AU - He, Yuan

AU - Knutson, Bruce A.

PY - 2018/8/8

Y1 - 2018/8/8

N2 - While structures of the RNA polymerase (Pol) II initiation complex have been resolved and extensively studied, the Pol I initiation complex remained elusive. Here, we review the recent structural analyses of the yeast Pol I transcription initiation complex that reveal several unique and unexpected Pol I-specific properties.

AB - While structures of the RNA polymerase (Pol) II initiation complex have been resolved and extensively studied, the Pol I initiation complex remained elusive. Here, we review the recent structural analyses of the yeast Pol I transcription initiation complex that reveal several unique and unexpected Pol I-specific properties.

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KW - RNA polymerase I

KW - pre-initiation complex

KW - promoter opening

KW - promoter recognition

KW - transcription initiation

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Breaking the mold: structures of the RNA polymerase I transcription complex reveal a new path for initiation

Abstract

Keywords

ASJC Scopus subject areas

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