Brainstem glioblastoma multiforme in a patient with NF1

John T. Fortunato, Brian Reys, Pawan Singh, Edward Pan

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


This case report presents the first known case of a brainstem glioblastoma multiforme (GBM) in a patient with neurofibromatosis type 1 (NF1). While research has proposed that larger germ-line mutations in NF1 may be the driving factor that predisposes patients with NF1 to high-grade astrocytomas, this patient had a nonsense mutation in the NF1 gene, suggesting a variant tumorigenesis. Limited data on targeted immunotherapy for NF1 patients with a GBM have been reported and more data are required before targetedtherapies could be proven as second-line treatment options.

Original languageEnglish (US)
Pages (from-to)4897-4900
Number of pages4
JournalAnticancer Research
Issue number8
StatePublished - Aug 2018


  • Brainstem
  • Glioblastoma multiforme
  • Immunotherapy
  • Neurofibromatosis type 1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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