Abstract
This case report presents the first known case of a brainstem glioblastoma multiforme (GBM) in a patient with neurofibromatosis type 1 (NF1). While research has proposed that larger germ-line mutations in NF1 may be the driving factor that predisposes patients with NF1 to high-grade astrocytomas, this patient had a nonsense mutation in the NF1 gene, suggesting a variant tumorigenesis. Limited data on targeted immunotherapy for NF1 patients with a GBM have been reported and more data are required before targetedtherapies could be proven as second-line treatment options.
Original language | English (US) |
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Pages (from-to) | 4897-4900 |
Number of pages | 4 |
Journal | Anticancer Research |
Volume | 38 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2018 |
Keywords
- Brainstem
- Glioblastoma multiforme
- Immunotherapy
- Neurofibromatosis type 1
ASJC Scopus subject areas
- Oncology
- Cancer Research