Brain metabolism patterns are sensitive to attentional effort associated with a tone recognition task

Henry H. Holcomb; Barry Gordon; Harry L. Loats; Edward Gastineau; Zuo Zhao; Deborah Medoff; Robert F. Dannals; Roger Woods; Carol A. Tamminga

doi:10.1016/0006-3223(95)00303-7

Brain metabolism patterns are sensitive to attentional effort associated with a tone recognition task

Henry H. Holcomb, Barry Gordon, Harry L. Loats, Edward Gastineau, Zuo Zhao, Deborah Medoff, Robert F. Dannals, Roger Woods, Carol A. Tamminga

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Using positron emission tomography with the tracer 18-fluoro-D-deoxyglucose, we assessed regional cerebral glucose utilization patterns (rCMRglu) associated with three performance levels in a forced choice, tone recognition task. Four normal subjects responded with one hand when they heard a high-frequency tone (1500 Hz), and with the other hand when they recognized a low-frequency tone (750 Hz). The EASY (EAS) condition accuracy average was 96%, the INTERMEDIATE level accuracy averaged 89%, and the DIFFICULT (DIF) recognition task accuracy average was 77%. Statistical parametric mapping (SPM94) analysis revealed that the DIF minus EAS contrast is associated with a marked metabolic elevation in the right middle and inferior temporal gyri and the gyrus fusiformis. The EAS minus DIF contrast revealed greater rCMRglu in the right medial geniculate body. Enhanced activity in right temporal lobe structures may reflect a role in auditory memory and 'image' visualization The medial geniculate enhancement may reflect tone frequency assessment.

Original language	English (US)
Pages (from-to)	1013-1022
Number of pages	10
Journal	Biological Psychiatry
Volume	39
Issue number	12
DOIs	https://doi.org/10.1016/0006-3223(95)00303-7
State	Published - Jun 15 1996

Keywords

Attention
Cortex
FDG
Positron emission tomography
Thalamus
Tone recognition

ASJC Scopus subject areas

Biological Psychiatry

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10.1016/0006-3223(95)00303-7

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title = "Brain metabolism patterns are sensitive to attentional effort associated with a tone recognition task",

abstract = "Using positron emission tomography with the tracer 18-fluoro-D-deoxyglucose, we assessed regional cerebral glucose utilization patterns (rCMRglu) associated with three performance levels in a forced choice, tone recognition task. Four normal subjects responded with one hand when they heard a high-frequency tone (1500 Hz), and with the other hand when they recognized a low-frequency tone (750 Hz). The EASY (EAS) condition accuracy average was 96%, the INTERMEDIATE level accuracy averaged 89%, and the DIFFICULT (DIF) recognition task accuracy average was 77%. Statistical parametric mapping (SPM94) analysis revealed that the DIF minus EAS contrast is associated with a marked metabolic elevation in the right middle and inferior temporal gyri and the gyrus fusiformis. The EAS minus DIF contrast revealed greater rCMRglu in the right medial geniculate body. Enhanced activity in right temporal lobe structures may reflect a role in auditory memory and 'image' visualization The medial geniculate enhancement may reflect tone frequency assessment.",

keywords = "Attention, Cortex, FDG, Positron emission tomography, Thalamus, Tone recognition",

author = "Holcomb, {Henry H.} and Barry Gordon and Loats, {Harry L.} and Edward Gastineau and Zuo Zhao and Deborah Medoff and Dannals, {Robert F.} and Roger Woods and Tamminga, {Carol A.}",

year = "1996",

month = jun,

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doi = "10.1016/0006-3223(95)00303-7",

language = "English (US)",

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T1 - Brain metabolism patterns are sensitive to attentional effort associated with a tone recognition task

AU - Holcomb, Henry H.

AU - Gordon, Barry

AU - Loats, Harry L.

AU - Gastineau, Edward

AU - Zhao, Zuo

AU - Medoff, Deborah

AU - Dannals, Robert F.

AU - Woods, Roger

AU - Tamminga, Carol A.

PY - 1996/6/15

Y1 - 1996/6/15

N2 - Using positron emission tomography with the tracer 18-fluoro-D-deoxyglucose, we assessed regional cerebral glucose utilization patterns (rCMRglu) associated with three performance levels in a forced choice, tone recognition task. Four normal subjects responded with one hand when they heard a high-frequency tone (1500 Hz), and with the other hand when they recognized a low-frequency tone (750 Hz). The EASY (EAS) condition accuracy average was 96%, the INTERMEDIATE level accuracy averaged 89%, and the DIFFICULT (DIF) recognition task accuracy average was 77%. Statistical parametric mapping (SPM94) analysis revealed that the DIF minus EAS contrast is associated with a marked metabolic elevation in the right middle and inferior temporal gyri and the gyrus fusiformis. The EAS minus DIF contrast revealed greater rCMRglu in the right medial geniculate body. Enhanced activity in right temporal lobe structures may reflect a role in auditory memory and 'image' visualization The medial geniculate enhancement may reflect tone frequency assessment.

AB - Using positron emission tomography with the tracer 18-fluoro-D-deoxyglucose, we assessed regional cerebral glucose utilization patterns (rCMRglu) associated with three performance levels in a forced choice, tone recognition task. Four normal subjects responded with one hand when they heard a high-frequency tone (1500 Hz), and with the other hand when they recognized a low-frequency tone (750 Hz). The EASY (EAS) condition accuracy average was 96%, the INTERMEDIATE level accuracy averaged 89%, and the DIFFICULT (DIF) recognition task accuracy average was 77%. Statistical parametric mapping (SPM94) analysis revealed that the DIF minus EAS contrast is associated with a marked metabolic elevation in the right middle and inferior temporal gyri and the gyrus fusiformis. The EAS minus DIF contrast revealed greater rCMRglu in the right medial geniculate body. Enhanced activity in right temporal lobe structures may reflect a role in auditory memory and 'image' visualization The medial geniculate enhancement may reflect tone frequency assessment.

KW - Attention

KW - Cortex

KW - FDG

KW - Positron emission tomography

KW - Thalamus

KW - Tone recognition

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Brain metabolism patterns are sensitive to attentional effort associated with a tone recognition task

Abstract

Keywords

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