Brain energy metabolism, cognitive function and down-regulated oxidative phosphorylation in Alzheimer disease

Stanley I. Rapoport; Kimmo Hatanpää; Daniel R. Brady; Krish Chandrasekaran

doi:10.1006/neur.1996.0065

Brain energy metabolism, cognitive function and down-regulated oxidative phosphorylation in Alzheimer disease

Stanley I. Rapoport, Kimmo Hatanpää, Daniel R. Brady, Krish Chandrasekaran

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Reduced brain glucose utilization in early stages of Alzheimer disease, as measured with in vivo positron emission tomography, reflects potentially reversible down-regulation of gene expression for oxidative phosphorylation within neuronal mitochondria. Such down-regulation may occur when neuronal energy demand is first reduced by synaptic dysfunction or loss.

Original language	English (US)
Pages (from-to)	473-476
Number of pages	4
Journal	Neurodegeneration
Volume	5
Issue number	4
DOIs	https://doi.org/10.1006/neur.1996.0065
State	Published - Dec 1996

Keywords

Alzheimer disease
Brain
Energy metabolism
Mitochondria
Oxidative phosphorylation
Positron emission tomography

ASJC Scopus subject areas

Pathology and Forensic Medicine
Neuropsychology and Physiological Psychology
Clinical Neurology

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10.1006/neur.1996.0065

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title = "Brain energy metabolism, cognitive function and down-regulated oxidative phosphorylation in Alzheimer disease",

abstract = "Reduced brain glucose utilization in early stages of Alzheimer disease, as measured with in vivo positron emission tomography, reflects potentially reversible down-regulation of gene expression for oxidative phosphorylation within neuronal mitochondria. Such down-regulation may occur when neuronal energy demand is first reduced by synaptic dysfunction or loss.",

keywords = "Alzheimer disease, Brain, Energy metabolism, Mitochondria, Oxidative phosphorylation, Positron emission tomography",

author = "Rapoport, {Stanley I.} and Kimmo Hatanp{\"a}{\"a} and Brady, {Daniel R.} and Krish Chandrasekaran",

year = "1996",

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AU - Rapoport, Stanley I.

AU - Hatanpää, Kimmo

AU - Brady, Daniel R.

AU - Chandrasekaran, Krish

PY - 1996/12

Y1 - 1996/12

N2 - Reduced brain glucose utilization in early stages of Alzheimer disease, as measured with in vivo positron emission tomography, reflects potentially reversible down-regulation of gene expression for oxidative phosphorylation within neuronal mitochondria. Such down-regulation may occur when neuronal energy demand is first reduced by synaptic dysfunction or loss.

AB - Reduced brain glucose utilization in early stages of Alzheimer disease, as measured with in vivo positron emission tomography, reflects potentially reversible down-regulation of gene expression for oxidative phosphorylation within neuronal mitochondria. Such down-regulation may occur when neuronal energy demand is first reduced by synaptic dysfunction or loss.

KW - Alzheimer disease

KW - Brain

KW - Energy metabolism

KW - Mitochondria

KW - Oxidative phosphorylation

KW - Positron emission tomography

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Brain energy metabolism, cognitive function and down-regulated oxidative phosphorylation in Alzheimer disease

Abstract

Keywords

ASJC Scopus subject areas

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