Brain elasticity changes with ventriculomegaly

F. H. Sklar, J. T. Diehl, C. W. Beyer, W. Kemp Clark

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


The pressure-volume relationship of brain elasticity was determined in 32 patients during servo-controlled variable-rate lumbar infusions to measure net cerebrospinal fluid (CSF) absorptive capacity. Several indices were used to estimate ventricular size from computerized tomography scans. The results show a linear relationship between ventricular size and the elasticity slope which relates the natural logarithm of pressure to volume. It follows that a hydrocephalic patient should show a greater intracranial pulse amplitude at a given pressure than does a patient with normal-sized ventricles. Although these elasticity changes may simply be the result of the ventriculomegaly, it seems possible that the pressure-volume elasticity relationship may be of etiological importance in disorders of the CSF system.

Original languageEnglish (US)
Pages (from-to)173-179
Number of pages7
JournalJournal of neurosurgery
Issue number2
StatePublished - 1980

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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