Blood Flow Reduction in Breast Tissue due to Mammographic Compression

David R. Busch, Regine Choe, Turgut Durduran, Daniel H. Friedman, Wesley B. Baker, Andrew D. Maidment, Mark A. Rosen, Mitchell D. Schnall, Arjun G. Yodh

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Rationale and objectives: This study measures hemodynamic properties such as blood flow and hemoglobin concentration and oxygenation in the healthy human breast under a wide range of compressive loads. Because many breast-imaging technologies derive contrast from the deformed breast, these load-dependent vascular responses affect contrast agent-enhanced and hemoglobin-based breast imaging. Methods: Diffuse optical and diffuse correlation spectroscopies were used to measure the concentrations of oxygenated and deoxygenated hemoglobin, lipid, water, and microvascular blood flow during axial breast compression in the parallel-plate transmission geometry. Results: Significant reductions (P <.01) in total hemoglobin concentration (~30%), blood oxygenation (~20%), and blood flow (~87%) were observed under applied pressures (forces) of up to 30 kPa (120 N) in 15 subjects. Lipid and water concentrations changed <10%. Conclusions: Imaging protocols based on injected contrast agents should account for variation in tissue blood flow due to mammographic compression. Similarly, imaging techniques that depend on endogenous blood contrasts will be affected by breast compression during imaging.

Original languageEnglish (US)
Pages (from-to)151-161
Number of pages11
JournalAcademic radiology
Issue number2
StatePublished - Feb 2014
Externally publishedYes


  • Blood flow
  • Breast cancer
  • Breast imaging
  • Diffuse optics
  • Mammographic compression

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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