Bladder EpiCheck urine test in the follow-up of NMIBC: a cost analysis

Marlène Charlotte Henrique Hekman, Stan Robert Willem Wijn, Yair Lotan, Tim Martin Govers, Johannes Alfred Witjes

Research output: Contribution to journalArticlepeer-review


Purpose: In the Netherlands yearly more than 5000 patients are diagnosed with non-muscle invasive bladder cancer (NMIBC). With a specificity of 88.0% and a negative predictive value (NPV) for high grade NMIBC of 99.3%, the Bladder EpiCheck (BE) urine test may be used in NMIBC to reduce the burden of follow-up cystoscopies. Methods: In this study a cost analysis of the BE follow-up strategy in the Dutch healthcare system was performed. In half of the follow-up appointments, BE was used as a rule-in for cystoscopy. In addition, the possible delay in recurrence detection was estimated. A cost calculation tool was developed using Microsoft Excel. Results: The BE strategy results in an estimated cost reduction of 8%, 4% and 9% in low, intermediate and high risk patients, respectively. In the Netherlands this may result in a cost reduction of approximately 1.6 million euro per year. The estimated delay in the detection of recurrent disease would be 3.9, 1.7 and 1.3 months in low, intermediate and high risk NMIBC patients respectively. Conclusion: To conclude, the BE can be used to reduce the costs of NMIBC follow-up, with a small delay in diagnosis of recurrent disease.

Original languageEnglish (US)
Pages (from-to)471-476
Number of pages6
JournalWorld journal of urology
Issue number2
StatePublished - Feb 2023


  • Biomarkers
  • Bladder cancer
  • Cost analysis
  • Monitoring

ASJC Scopus subject areas

  • Urology


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