Bisphosphonate use in children with bone disease

Janelle Hickey, David Lemons, Pamela Waber, Mouin G. Seikaly

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Except for OI and osteoporosis, the clinical data supporting bisphosphonate use in metabolic bone disease in children are sparse and largely anecdotal. Currently, physicians prescribe these drugs for compassionate use in conditions deemed otherwise medically untreatable. Several controversial issues, such as effects on osteotomy healing, statural growth, and risk factors for osteonecrosis of the jaw, remain to be addressed. Additional well-designed studies are needed to establish or refute the utility of bisphosphonates in other clinical pediatric conditions.

Original languageEnglish (US)
Pages (from-to)638-644
Number of pages7
JournalJournal of the American Academy of Orthopaedic Surgeons
Issue number12
StatePublished - Jan 1 2006

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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