TY - JOUR
T1 - Bisphosphonate use in children with bone disease
AU - Hickey, Janelle
AU - Lemons, David
AU - Waber, Pamela
AU - Seikaly, Mouin G.
PY - 2006
Y1 - 2006
N2 - Except for OI and osteoporosis, the clinical data supporting bisphosphonate use in metabolic bone disease in children are sparse and largely anecdotal. Currently, physicians prescribe these drugs for compassionate use in conditions deemed otherwise medically untreatable. Several controversial issues, such as effects on osteotomy healing, statural growth, and risk factors for osteonecrosis of the jaw, remain to be addressed. Additional well-designed studies are needed to establish or refute the utility of bisphosphonates in other clinical pediatric conditions.
AB - Except for OI and osteoporosis, the clinical data supporting bisphosphonate use in metabolic bone disease in children are sparse and largely anecdotal. Currently, physicians prescribe these drugs for compassionate use in conditions deemed otherwise medically untreatable. Several controversial issues, such as effects on osteotomy healing, statural growth, and risk factors for osteonecrosis of the jaw, remain to be addressed. Additional well-designed studies are needed to establish or refute the utility of bisphosphonates in other clinical pediatric conditions.
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U2 - 10.5435/00124635-200611000-00006
DO - 10.5435/00124635-200611000-00006
M3 - Review article
C2 - 17077335
AN - SCOPUS:33947662998
SN - 1067-151X
VL - 14
SP - 638
EP - 644
JO - Journal of the American Academy of Orthopaedic Surgeons
JF - Journal of the American Academy of Orthopaedic Surgeons
IS - 12
ER -