TY - JOUR
T1 - Biomolecular Condensates in the Nucleus
AU - Sabari, Benjamin R.
AU - Dall'Agnese, Alessandra
AU - Young, Richard A.
N1 - Funding Information:
We thank Salman Banani, Jon Henninger, and Adam Klosin for comments on the manuscript. This work was supported by NIH (National Institutes of Health, USA) grants GM123511, MH104610, CA213333 and CA155258 (R.A.Y.), NSF (National Science Foundation, USA) grant PHY1743900 (R.A.Y.), St. Jude Children's Research Hospital (R.A.Y.), Novo Nordisk (R.A.Y.), Damon Runyon Cancer Research Foundation Fellowship 2309-17 (B.R.S.), CPRIT (Cancer Prevention and Research Institute of Texas, USA) grant RR190090 (B.R.S.), and Hope Funds for Cancer Research (A.D.). R.A.Y. is a founder and shareholder of Syros Pharmaceuticals, Camp4 Therapeutics, Omega Therapeutics, and Dewpoint Therapeutics.
Funding Information:
We thank Salman Banani, Jon Henninger, and Adam Klosin for comments on the manuscript. This work was supported by NIH (National Institutes of Health, USA) grants GM123511 , MH104610 , CA213333 and CA155258 (R.A.Y.), NSF (National Science Foundation, USA) grant PHY1743900 (R.A.Y.), St. Jude Children’s Research Hospital (R.A.Y.), Novo Nordisk (R.A.Y.), Damon Runyon Cancer Research Foundation Fellowship 2309-17 (B.R.S.), CPRIT (Cancer Prevention and Research Institute of Texas, USA) grant RR190090 (B.R.S.), and Hope Funds for Cancer Research (A.D.). R.A.Y. is a founder and shareholder of Syros Pharmaceuticals, Camp4 Therapeutics, Omega Therapeutics, and Dewpoint Therapeutics.
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/11
Y1 - 2020/11
N2 - Nuclear processes such as DNA replication, transcription, and RNA processing each depend on the concerted action of many different protein and RNA molecules. How biomolecules with shared functions find their way to specific locations has been assumed to occur largely by diffusion-mediated collisions. Recent studies have shown that many nuclear processes occur within condensates that compartmentalize and concentrate the protein and RNA molecules required for each process, typically at specific genomic loci. These condensates have common features and emergent properties that provide the cell with regulatory capabilities beyond canonical molecular regulatory mechanisms. We describe here the shared features of nuclear condensates, the components that produce locus-specific condensates, elements of specificity, and the emerging understanding of mechanisms regulating these compartments.
AB - Nuclear processes such as DNA replication, transcription, and RNA processing each depend on the concerted action of many different protein and RNA molecules. How biomolecules with shared functions find their way to specific locations has been assumed to occur largely by diffusion-mediated collisions. Recent studies have shown that many nuclear processes occur within condensates that compartmentalize and concentrate the protein and RNA molecules required for each process, typically at specific genomic loci. These condensates have common features and emergent properties that provide the cell with regulatory capabilities beyond canonical molecular regulatory mechanisms. We describe here the shared features of nuclear condensates, the components that produce locus-specific condensates, elements of specificity, and the emerging understanding of mechanisms regulating these compartments.
KW - biomolecular condensates
KW - chromatin regulation
KW - condensate dysregulation
KW - condensate regulation
KW - gene regulation
KW - nuclear organization
UR - http://www.scopus.com/inward/record.url?scp=85087944177&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85087944177&partnerID=8YFLogxK
U2 - 10.1016/j.tibs.2020.06.007
DO - 10.1016/j.tibs.2020.06.007
M3 - Review article
C2 - 32684431
AN - SCOPUS:85087944177
SN - 0968-0004
VL - 45
SP - 961
EP - 977
JO - Trends in biochemical sciences
JF - Trends in biochemical sciences
IS - 11
ER -