Biomimetic nanocarrier for direct cytosolic drug delivery

Zhihong Zhang, Weiguo Cao, Honglin Jin, Jonathan F. Lovell, Mi Yang, Lili Ding, Juan Chen, Ian Corbin, Qingming Luo, Gang Zheng

Research output: Contribution to journalArticlepeer-review

142 Scopus citations


Getting straight to the point: A peptide-phospholipid-based biomimetic nanocarrier was developed that can transport cargo molecules directly into cytosolic compartments through a non-endocytotic uptake mechanism mediated by scavenger receptor class B type I (SR-BI ; see schematic illustration). The fluorescent image shows the cytosolic localization of a dye (red) delivered by the nanocarrier to SR-BI-positive cells (nuclei: blue, membranes: cyan).

Original languageEnglish (US)
Pages (from-to)9171-9175
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number48
StatePublished - Nov 16 2009


  • Biomimetic structures
  • Cytosol
  • Drug delivery
  • Nanocarriers
  • Peptides

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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