Biomimetic nanocarrier for direct cytosolic drug delivery

Zhihong Zhang; Weiguo Cao; Honglin Jin; Jonathan F. Lovell; Mi Yang; Lili Ding; Juan Chen; Ian Corbin; Qingming Luo; Gang Zheng

doi:10.1002/anie.200903112

Biomimetic nanocarrier for direct cytosolic drug delivery

Zhihong Zhang, Weiguo Cao, Honglin Jin, Jonathan F. Lovell, Mi Yang, Lili Ding, Juan Chen, Ian Corbin, Qingming Luo, Gang Zheng

Research output: Contribution to journal › Article › peer-review

148 Scopus citations

Abstract

Getting straight to the point: A peptide-phospholipid-based biomimetic nanocarrier was developed that can transport cargo molecules directly into cytosolic compartments through a non-endocytotic uptake mechanism mediated by scavenger receptor class B type I (SR-BI ; see schematic illustration). The fluorescent image shows the cytosolic localization of a dye (red) delivered by the nanocarrier to SR-BI-positive cells (nuclei: blue, membranes: cyan).

Original language	English (US)
Pages (from-to)	9171-9175
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	48
DOIs	https://doi.org/10.1002/anie.200903112
State	Published - Nov 16 2009

Keywords

Biomimetic structures
Cytosol
Drug delivery
Nanocarriers
Peptides

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200903112

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abstract = "Getting straight to the point: A peptide-phospholipid-based biomimetic nanocarrier was developed that can transport cargo molecules directly into cytosolic compartments through a non-endocytotic uptake mechanism mediated by scavenger receptor class B type I (SR-BI ; see schematic illustration). The fluorescent image shows the cytosolic localization of a dye (red) delivered by the nanocarrier to SR-BI-positive cells (nuclei: blue, membranes: cyan).",

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AU - Zhang, Zhihong

AU - Cao, Weiguo

AU - Jin, Honglin

AU - Lovell, Jonathan F.

AU - Yang, Mi

AU - Ding, Lili

AU - Chen, Juan

AU - Corbin, Ian

AU - Luo, Qingming

AU - Zheng, Gang

PY - 2009/11/16

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AB - Getting straight to the point: A peptide-phospholipid-based biomimetic nanocarrier was developed that can transport cargo molecules directly into cytosolic compartments through a non-endocytotic uptake mechanism mediated by scavenger receptor class B type I (SR-BI ; see schematic illustration). The fluorescent image shows the cytosolic localization of a dye (red) delivered by the nanocarrier to SR-BI-positive cells (nuclei: blue, membranes: cyan).

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KW - Cytosol

KW - Drug delivery

KW - Nanocarriers

KW - Peptides

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Biomimetic nanocarrier for direct cytosolic drug delivery

Abstract

Keywords

ASJC Scopus subject areas

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