Biomimetic nanocarrier for direct cytosolic drug delivery

Zhihong Zhang, Weiguo Cao, Honglin Jin, Jonathan F. Lovell, Mi Yang, Lili Ding, Juan Chen, Ian Corbin, Qingming Luo, Gang Zheng

Research output: Contribution to journalArticlepeer-review

146 Scopus citations

Abstract

Getting straight to the point: A peptide-phospholipid-based biomimetic nanocarrier was developed that can transport cargo molecules directly into cytosolic compartments through a non-endocytotic uptake mechanism mediated by scavenger receptor class B type I (SR-BI ; see schematic illustration). The fluorescent image shows the cytosolic localization of a dye (red) delivered by the nanocarrier to SR-BI-positive cells (nuclei: blue, membranes: cyan).

Original languageEnglish (US)
Pages (from-to)9171-9175
Number of pages5
JournalAngewandte Chemie - International Edition
Volume48
Issue number48
DOIs
StatePublished - Nov 16 2009

Keywords

  • Biomimetic structures
  • Cytosol
  • Drug delivery
  • Nanocarriers
  • Peptides

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry

Fingerprint

Dive into the research topics of 'Biomimetic nanocarrier for direct cytosolic drug delivery'. Together they form a unique fingerprint.

Cite this