Bioerosion of Synthetic Sling Explants

Katherine E. Washington; Gina Quiram; Angela Nguyen; Ruvanthi N. Kularatne; Majid Minary-Jolandan; Philippe Zimmern; Mihaela C. Stefan

doi:10.1021/acsbiomaterials.7b00614

Bioerosion of Synthetic Sling Explants

Katherine E. Washington, Gina Quiram, Angela Nguyen, Ruvanthi N. Kularatne, Majid Minary-Jolandan, Philippe Zimmern, Mihaela C. Stefan

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

This study was performed to investigate the changes over time in polypropylene (PP) mesh explants from women with stress urinary incontinence originally treated with a midurethral PP sling. Following Institutional Review Board (IRB) approval, 10 PP explants removed for pain or obstructive symptoms between January and June 2016 were analyzed through various techniques to determine the degradation of the material in vivo. Exclusion criteria were exposed or infected mesh sling or sling in place for less than six months. One pristine control was studied for comparison. The explant samples were analyzed with scanning electron microscopy to visualize the surface defects as well as infrared spectroscopy and energy dispersive X-ray spectroscopy to determine if the degradation was oxidative in nature. The results show qualitative and quantitative bioerosion over the surface of the explant samples and an increase in the content of oxygen pointing toward oxidative degradation occurring in vivo.

Original language	English (US)
Pages (from-to)	2598-2605
Number of pages	8
Journal	ACS Biomaterials Science and Engineering
Volume	3
Issue number	10
DOIs	https://doi.org/10.1021/acsbiomaterials.7b00614
State	Published - Oct 9 2017

Keywords

oxidative degradation
polypropylene
sling mesh explant
surgical mesh
synthetic sling

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering

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10.1021/acsbiomaterials.7b00614

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title = "Bioerosion of Synthetic Sling Explants",

abstract = "This study was performed to investigate the changes over time in polypropylene (PP) mesh explants from women with stress urinary incontinence originally treated with a midurethral PP sling. Following Institutional Review Board (IRB) approval, 10 PP explants removed for pain or obstructive symptoms between January and June 2016 were analyzed through various techniques to determine the degradation of the material in vivo. Exclusion criteria were exposed or infected mesh sling or sling in place for less than six months. One pristine control was studied for comparison. The explant samples were analyzed with scanning electron microscopy to visualize the surface defects as well as infrared spectroscopy and energy dispersive X-ray spectroscopy to determine if the degradation was oxidative in nature. The results show qualitative and quantitative bioerosion over the surface of the explant samples and an increase in the content of oxygen pointing toward oxidative degradation occurring in vivo.",

keywords = "oxidative degradation, polypropylene, sling mesh explant, surgical mesh, synthetic sling",

author = "Washington, {Katherine E.} and Gina Quiram and Angela Nguyen and Kularatne, {Ruvanthi N.} and Majid Minary-Jolandan and Philippe Zimmern and Stefan, {Mihaela C.}",

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T1 - Bioerosion of Synthetic Sling Explants

AU - Washington, Katherine E.

AU - Quiram, Gina

AU - Nguyen, Angela

AU - Kularatne, Ruvanthi N.

AU - Minary-Jolandan, Majid

AU - Zimmern, Philippe

AU - Stefan, Mihaela C.

PY - 2017/10/9

Y1 - 2017/10/9

N2 - This study was performed to investigate the changes over time in polypropylene (PP) mesh explants from women with stress urinary incontinence originally treated with a midurethral PP sling. Following Institutional Review Board (IRB) approval, 10 PP explants removed for pain or obstructive symptoms between January and June 2016 were analyzed through various techniques to determine the degradation of the material in vivo. Exclusion criteria were exposed or infected mesh sling or sling in place for less than six months. One pristine control was studied for comparison. The explant samples were analyzed with scanning electron microscopy to visualize the surface defects as well as infrared spectroscopy and energy dispersive X-ray spectroscopy to determine if the degradation was oxidative in nature. The results show qualitative and quantitative bioerosion over the surface of the explant samples and an increase in the content of oxygen pointing toward oxidative degradation occurring in vivo.

AB - This study was performed to investigate the changes over time in polypropylene (PP) mesh explants from women with stress urinary incontinence originally treated with a midurethral PP sling. Following Institutional Review Board (IRB) approval, 10 PP explants removed for pain or obstructive symptoms between January and June 2016 were analyzed through various techniques to determine the degradation of the material in vivo. Exclusion criteria were exposed or infected mesh sling or sling in place for less than six months. One pristine control was studied for comparison. The explant samples were analyzed with scanning electron microscopy to visualize the surface defects as well as infrared spectroscopy and energy dispersive X-ray spectroscopy to determine if the degradation was oxidative in nature. The results show qualitative and quantitative bioerosion over the surface of the explant samples and an increase in the content of oxygen pointing toward oxidative degradation occurring in vivo.

KW - oxidative degradation

KW - polypropylene

KW - sling mesh explant

KW - surgical mesh

KW - synthetic sling

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Bioerosion of Synthetic Sling Explants

Abstract

Keywords

ASJC Scopus subject areas

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