Biodegradable pH-sensing dendritic nanoprobes for near-infrared fluorescence lifetime and intensity imaging

Adah Almutairi; Steven J. Guillaudeu; Mikhail Y. Berezin; Samuel Achilefu; Jean M.J. Fréchet

doi:10.1021/ja078147e

Biodegradable pH-sensing dendritic nanoprobes for near-infrared fluorescence lifetime and intensity imaging

Adah Almutairi, Steven J. Guillaudeu, Mikhail Y. Berezin, Samuel Achilefu, Jean M.J. Fréchet

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

The overproduction of acidic byproducts is implicated in the development of numerous diseases, and there is currently great interest in developing contrast agents that can image acidic tissue in vivo. Here we report a biodegradable pH-sensing near-infrared (NIR) nanoprobe capable of providing both fluorescence intensity amplification and lifetime information. The pH-sensing NIR nanoprobe is synthesized, in six high yielding and scalable steps, and functions within the tissue transparency window. Both fluorescence intensity and lifetime provided complementary physiological (low pH) and molecular (released fluorophore binding to albumin) information, respectively.

Original language	English (US)
Pages (from-to)	444-445
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	130
Issue number	2
DOIs	https://doi.org/10.1021/ja078147e
State	Published - Jan 16 2008
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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abstract = "The overproduction of acidic byproducts is implicated in the development of numerous diseases, and there is currently great interest in developing contrast agents that can image acidic tissue in vivo. Here we report a biodegradable pH-sensing near-infrared (NIR) nanoprobe capable of providing both fluorescence intensity amplification and lifetime information. The pH-sensing NIR nanoprobe is synthesized, in six high yielding and scalable steps, and functions within the tissue transparency window. Both fluorescence intensity and lifetime provided complementary physiological (low pH) and molecular (released fluorophore binding to albumin) information, respectively.",

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AU - Guillaudeu, Steven J.

AU - Berezin, Mikhail Y.

AU - Achilefu, Samuel

AU - Fréchet, Jean M.J.

PY - 2008/1/16

Y1 - 2008/1/16

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AB - The overproduction of acidic byproducts is implicated in the development of numerous diseases, and there is currently great interest in developing contrast agents that can image acidic tissue in vivo. Here we report a biodegradable pH-sensing near-infrared (NIR) nanoprobe capable of providing both fluorescence intensity amplification and lifetime information. The pH-sensing NIR nanoprobe is synthesized, in six high yielding and scalable steps, and functions within the tissue transparency window. Both fluorescence intensity and lifetime provided complementary physiological (low pH) and molecular (released fluorophore binding to albumin) information, respectively.

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Biodegradable pH-sensing dendritic nanoprobes for near-infrared fluorescence lifetime and intensity imaging

Abstract

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