TY - JOUR
T1 - Binding sites for endothelin-1 in rat tissues
T2 - An autoradiographic study
AU - Koseki, C.
AU - Imai, M.
AU - Hirata, Y.
AU - Yanagisawa, Masashi
AU - Masaki, T.
PY - 1989
Y1 - 1989
N2 - By tissue autoradiography in the rat, we demonstrated that receptors for endothelin-1 (ET-1) were distributed not only in the cardiovascular system but also in the noncardiovascular organs including the brain, lung, intestine, etc. In the brain, the receptors were mainly found in the basal ganglia and brainstem, in which nuclei are known to be cardiovascular regulatory sites. In addition to its direct vasoconstricting action, ET-1 may exert neural cardiovascular control as a neuropeptide.
AB - By tissue autoradiography in the rat, we demonstrated that receptors for endothelin-1 (ET-1) were distributed not only in the cardiovascular system but also in the noncardiovascular organs including the brain, lung, intestine, etc. In the brain, the receptors were mainly found in the basal ganglia and brainstem, in which nuclei are known to be cardiovascular regulatory sites. In addition to its direct vasoconstricting action, ET-1 may exert neural cardiovascular control as a neuropeptide.
KW - Autoradiography
KW - Cardiovascular regulatory nucleus
KW - Central nervous system
KW - Endothelin-1
KW - Receptor
KW - Vasoconstrictor
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U2 - 10.1097/00005344-198900135-00040
DO - 10.1097/00005344-198900135-00040
M3 - Article
C2 - 2473293
AN - SCOPUS:0024506467
SN - 0160-2446
VL - 13
SP - S153-S154
JO - Journal of Cardiovascular Pharmacology
JF - Journal of Cardiovascular Pharmacology
ER -