Binding sites for endothelin-1 in rat tissues: An autoradiographic study

C. Koseki, M. Imai, Y. Hirata, Masashi Yanagisawa, T. Masaki

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


By tissue autoradiography in the rat, we demonstrated that receptors for endothelin-1 (ET-1) were distributed not only in the cardiovascular system but also in the noncardiovascular organs including the brain, lung, intestine, etc. In the brain, the receptors were mainly found in the basal ganglia and brainstem, in which nuclei are known to be cardiovascular regulatory sites. In addition to its direct vasoconstricting action, ET-1 may exert neural cardiovascular control as a neuropeptide.

Original languageEnglish (US)
Pages (from-to)S153-S154
JournalJournal of Cardiovascular Pharmacology
StatePublished - 1989


  • Autoradiography
  • Cardiovascular regulatory nucleus
  • Central nervous system
  • Endothelin-1
  • Receptor
  • Vasoconstrictor

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine


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