Bimodal MR-PET agent for quantitative pH imaging

Luca Frullano; Ciprian Catana; Thomas Benner; A. Dean Sherry; Peter Caravan

doi:10.1002/anie.201000075

Bimodal MR-PET agent for quantitative pH imaging

Luca Frullano, Ciprian Catana, Thomas Benner, A. Dean Sherry, Peter Caravan

Research output: Contribution to journal › Article › peer-review

134 Scopus citations

Abstract

(Figure Presented) Two unknowns: The relaxivity of activatable magnetic resonance (MR) contrast agents depends on environmental factors, such as the pH value or enzymatic activity, but the MR signal depends on relaxivity and agent concentration. Simultaneous positron emission tomography (PET) and MR imaging (MRI) with the bimodal, pHresponsive M R-PET agent shown enabled the direct determination of concentration and T₁, and hence the pH value.

Original language	English (US)
Pages (from-to)	2382-2384
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	13
DOIs	https://doi.org/10.1002/anie.201000075
State	Published - Mar 22 2010

Keywords

Gadolinium
Imaging agents
Magnetic resonance imaging
Ph imaging
Positron emission tomography

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.201000075

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abstract = "(Figure Presented) Two unknowns: The relaxivity of activatable magnetic resonance (MR) contrast agents depends on environmental factors, such as the pH value or enzymatic activity, but the MR signal depends on relaxivity and agent concentration. Simultaneous positron emission tomography (PET) and MR imaging (MRI) with the bimodal, pHresponsive M R-PET agent shown enabled the direct determination of concentration and T1, and hence the pH value.",

keywords = "Gadolinium, Imaging agents, Magnetic resonance imaging, Ph imaging, Positron emission tomography",

author = "Luca Frullano and Ciprian Catana and Thomas Benner and Sherry, {A. Dean} and Peter Caravan",

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T1 - Bimodal MR-PET agent for quantitative pH imaging

AU - Frullano, Luca

AU - Catana, Ciprian

AU - Benner, Thomas

AU - Sherry, A. Dean

AU - Caravan, Peter

PY - 2010/3/22

Y1 - 2010/3/22

N2 - (Figure Presented) Two unknowns: The relaxivity of activatable magnetic resonance (MR) contrast agents depends on environmental factors, such as the pH value or enzymatic activity, but the MR signal depends on relaxivity and agent concentration. Simultaneous positron emission tomography (PET) and MR imaging (MRI) with the bimodal, pHresponsive M R-PET agent shown enabled the direct determination of concentration and T1, and hence the pH value.

AB - (Figure Presented) Two unknowns: The relaxivity of activatable magnetic resonance (MR) contrast agents depends on environmental factors, such as the pH value or enzymatic activity, but the MR signal depends on relaxivity and agent concentration. Simultaneous positron emission tomography (PET) and MR imaging (MRI) with the bimodal, pHresponsive M R-PET agent shown enabled the direct determination of concentration and T1, and hence the pH value.

KW - Gadolinium

KW - Imaging agents

KW - Magnetic resonance imaging

KW - Ph imaging

KW - Positron emission tomography

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 13

ER -

Bimodal MR-PET agent for quantitative pH imaging

Abstract

Keywords

ASJC Scopus subject areas

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