Bimodal MR-PET agent for quantitative pH imaging

Luca Frullano, Ciprian Catana, Thomas Benner, A. Dean Sherry, Peter Caravan

Research output: Contribution to journalArticlepeer-review

134 Scopus citations


(Figure Presented) Two unknowns: The relaxivity of activatable magnetic resonance (MR) contrast agents depends on environmental factors, such as the pH value or enzymatic activity, but the MR signal depends on relaxivity and agent concentration. Simultaneous positron emission tomography (PET) and MR imaging (MRI) with the bimodal, pHresponsive M R-PET agent shown enabled the direct determination of concentration and T1, and hence the pH value.

Original languageEnglish (US)
Pages (from-to)2382-2384
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number13
StatePublished - Mar 22 2010


  • Gadolinium
  • Imaging agents
  • Magnetic resonance imaging
  • Ph imaging
  • Positron emission tomography

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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