Beth Levine’s Legacy: From the Discovery of BECN1 to Therapies. A Mentees’ Perspective

Zhenyi An; Wei Chung Chiang; Álvaro F. Fernández; Luis H. Franco; Cong Cong He; Shu Yi Huang; Eunmyong Lee; Yang Liu; Salwa Sebti; Sanae Shoji-Kawata; Shyam Sirasanagandla; Richard C. Wang; Yongjie Wei; Yuting Zhao; Silvia Vega-Rubin-de-Celis

doi:10.3389/fcell.2022.891332

Beth Levine’s Legacy: From the Discovery of BECN1 to Therapies. A Mentees’ Perspective

Zhenyi An, Wei Chung Chiang, Álvaro F. Fernández, Luis H. Franco, Cong Cong He, Shu Yi Huang, Eunmyong Lee, Yang Liu, Salwa Sebti, Sanae Shoji-Kawata, Shyam Sirasanagandla, Richard C. Wang, Yongjie Wei, Yuting Zhao, Silvia Vega-Rubin-de-Celis

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

With great sadness, the scientific community received the news of the loss of Beth Levine on 15 June 2020. Dr. Levine was a pioneer in the autophagy field and work in her lab led not only to a better understanding of the molecular mechanisms regulating the pathway, but also its implications in multiple physiological and pathological conditions, including its role in development, host defense, tumorigenesis, aging or metabolism. This review does not aim to provide a comprehensive view of autophagy, but rather an outline of some of the discoveries made by the group of Beth Levine, from the perspective of some of her own mentees, hoping to honor her legacy in science.

Original language	English (US)
Article number	891332
Journal	Frontiers in Cell and Developmental Biology
Volume	10
DOIs	https://doi.org/10.3389/fcell.2022.891332
State	Published - Jun 27 2022

Keywords

BECN1
Beth Levine
aging
cancer
infectious diseases
macroautophagy
metabolism
selective autophagy

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.3389/fcell.2022.891332

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An, Z., Chiang, W. C., Fernández, Á. F., Franco, L. H., He, C. C., Huang, S. Y., Lee, E., Liu, Y., Sebti, S., Shoji-Kawata, S., Sirasanagandla, S., Wang, R. C., Wei, Y., Zhao, Y., & Vega-Rubin-de-Celis, S. (2022). Beth Levine’s Legacy: From the Discovery of BECN1 to Therapies. A Mentees’ Perspective. Frontiers in Cell and Developmental Biology, 10, Article 891332. https://doi.org/10.3389/fcell.2022.891332

An, Z, Chiang, WC, Fernández, ÁF, Franco, LH, He, CC, Huang, SY, Lee, E, Liu, Y, Sebti, S, Shoji-Kawata, S, Sirasanagandla, S, Wang, RC, Wei, Y, Zhao, Y & Vega-Rubin-de-Celis, S 2022, 'Beth Levine’s Legacy: From the Discovery of BECN1 to Therapies. A Mentees’ Perspective', Frontiers in Cell and Developmental Biology, vol. 10, 891332. https://doi.org/10.3389/fcell.2022.891332

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abstract = "With great sadness, the scientific community received the news of the loss of Beth Levine on 15 June 2020. Dr. Levine was a pioneer in the autophagy field and work in her lab led not only to a better understanding of the molecular mechanisms regulating the pathway, but also its implications in multiple physiological and pathological conditions, including its role in development, host defense, tumorigenesis, aging or metabolism. This review does not aim to provide a comprehensive view of autophagy, but rather an outline of some of the discoveries made by the group of Beth Levine, from the perspective of some of her own mentees, hoping to honor her legacy in science.",

keywords = "BECN1, Beth Levine, aging, cancer, infectious diseases, macroautophagy, metabolism, selective autophagy",

author = "Zhenyi An and Chiang, {Wei Chung} and Fern{\'a}ndez, {{\'A}lvaro F.} and Franco, {Luis H.} and He, {Cong Cong} and Huang, {Shu Yi} and Eunmyong Lee and Yang Liu and Salwa Sebti and Sanae Shoji-Kawata and Shyam Sirasanagandla and Wang, {Richard C.} and Yongjie Wei and Yuting Zhao and Silvia Vega-Rubin-de-Celis",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 An, Chiang, Fern{\'a}ndez, Franco, He, Huang, Lee, Liu, Sebti, Shoji-Kawata, Sirasanagandla, Wang, Wei, Zhao and Vega-Rubin-de-Celis.",

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AU - Fernández, Álvaro F.

AU - Franco, Luis H.

AU - He, Cong Cong

AU - Huang, Shu Yi

AU - Lee, Eunmyong

AU - Liu, Yang

AU - Sebti, Salwa

AU - Shoji-Kawata, Sanae

AU - Sirasanagandla, Shyam

AU - Wang, Richard C.

AU - Wei, Yongjie

AU - Zhao, Yuting

AU - Vega-Rubin-de-Celis, Silvia

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AB - With great sadness, the scientific community received the news of the loss of Beth Levine on 15 June 2020. Dr. Levine was a pioneer in the autophagy field and work in her lab led not only to a better understanding of the molecular mechanisms regulating the pathway, but also its implications in multiple physiological and pathological conditions, including its role in development, host defense, tumorigenesis, aging or metabolism. This review does not aim to provide a comprehensive view of autophagy, but rather an outline of some of the discoveries made by the group of Beth Levine, from the perspective of some of her own mentees, hoping to honor her legacy in science.

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KW - metabolism

KW - selective autophagy

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Beth Levine’s Legacy: From the Discovery of BECN1 to Therapies. A Mentees’ Perspective

Abstract

Keywords

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