@article{6a55f0b107304c3aa72d82972b20655d,
title = "Beth Levine{\textquoteright}s Legacy: From the Discovery of BECN1 to Therapies. A Mentees{\textquoteright} Perspective",
abstract = "With great sadness, the scientific community received the news of the loss of Beth Levine on 15 June 2020. Dr. Levine was a pioneer in the autophagy field and work in her lab led not only to a better understanding of the molecular mechanisms regulating the pathway, but also its implications in multiple physiological and pathological conditions, including its role in development, host defense, tumorigenesis, aging or metabolism. This review does not aim to provide a comprehensive view of autophagy, but rather an outline of some of the discoveries made by the group of Beth Levine, from the perspective of some of her own mentees, hoping to honor her legacy in science.",
keywords = "BECN1, Beth Levine, aging, cancer, infectious diseases, macroautophagy, metabolism, selective autophagy",
author = "Zhenyi An and Chiang, {Wei Chung} and Fern{\'a}ndez, {{\'A}lvaro F.} and Franco, {Luis H.} and He, {Cong Cong} and Huang, {Shu Yi} and Eunmyong Lee and Yang Liu and Salwa Sebti and Sanae Shoji-Kawata and Shyam Sirasanagandla and Wang, {Richard C.} and Yongjie Wei and Yuting Zhao and Silvia Vega-Rubin-de-Celis",
note = "Funding Information: CH was supported by a NIH R01 DK113170, NIH R01 DK123447, and Bright Focus Foundation Alzheimer{\textquoteright}s Disease Research Award. LF would like to thank the funding agencies Coordena{\c c}{\~a}o de Aperfei{\c c}oamento de Pessoal de N{\'i}vel Superior (CAPES) grant 306834/2019-7, Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico (CNPq) grant 426073/2018-5, and Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa do Estado de Minas Gerais (FAPEMIG) grant APQ-00602-21. SV-R was supported by a German Research Foundation (DFG) grant (VE1153/1-1). WCC was supported by Ministry of Science and Technology of Taiwan (MOST) grant, MOST 110-2628-B-A49A-513, National Health Research Institutes (NHRI) grant, NHRI-EX111-11009SC, and Yen Tjing Ling Medical Foundation, CI-111-34. Funding Information: We acknowledge support from the Open Access Publication Fund of the University of Duisburg-Essen. Publisher Copyright: Copyright {\textcopyright} 2022 An, Chiang, Fern{\'a}ndez, Franco, He, Huang, Lee, Liu, Sebti, Shoji-Kawata, Sirasanagandla, Wang, Wei, Zhao and Vega-Rubin-de-Celis.",
year = "2022",
month = jun,
day = "27",
doi = "10.3389/fcell.2022.891332",
language = "English (US)",
volume = "10",
journal = "Frontiers in Cell and Developmental Biology",
issn = "2296-634X",
publisher = "Frontiers Media S. A.",
}