TY - JOUR
T1 - Behavioral effects of congenital ventromedial prefrontal cortex malformation
AU - Boes, Aaron D.
AU - Grafft, Amanda H.
AU - Joshi, Charuta
AU - Chuang, Nathaniel A.
AU - Nopoulos, Peg
AU - Anderson, Steven W.
N1 - Funding Information:
We would like to thank BW and his family for their help in presenting his story. We thank Martin Cassell, Ph.D., for his assistance with neuroanatomy and further defining the lesion. We also thank Rosalind B. Dietrich, who carefully reviewed the MRI data and offered many helpful suggestions in accurately characterizing the lesion. This research was supported by National Institute of Neurological Disorders and Stroke (NINDS)PO19632. No authors report any conflicts of interest, financial or otherwise.
PY - 2011/12/2
Y1 - 2011/12/2
N2 - Background: A detailed behavioral profile associated with focal congenital malformation of the ventromedial prefrontal cortex (vmPFC) has not been reported previously. Here we describe a 14 year-old boy, B.W., with neurological and psychiatric sequelae stemming from focal cortical malformation of the left vmPFC.Case Presentation: B.W.'s behavior has been characterized through extensive review Patience of clinical and personal records along with behavioral and neuropsychological testing. A central feature of the behavioral profile is severe antisocial behavior. He is aggressive, manipulative, and callous; features consistent with psychopathy. Other problems include: egocentricity, impulsivity, hyperactivity, lack of empathy, lack of respect for authority, impaired moral judgment, an inability to plan ahead, and poor frustration tolerance.Conclusions: The vmPFC has a profound contribution to the development of human prosocial behavior. B.W. demonstrates how a congenital lesion to this cortical region severely disrupts this process.
AB - Background: A detailed behavioral profile associated with focal congenital malformation of the ventromedial prefrontal cortex (vmPFC) has not been reported previously. Here we describe a 14 year-old boy, B.W., with neurological and psychiatric sequelae stemming from focal cortical malformation of the left vmPFC.Case Presentation: B.W.'s behavior has been characterized through extensive review Patience of clinical and personal records along with behavioral and neuropsychological testing. A central feature of the behavioral profile is severe antisocial behavior. He is aggressive, manipulative, and callous; features consistent with psychopathy. Other problems include: egocentricity, impulsivity, hyperactivity, lack of empathy, lack of respect for authority, impaired moral judgment, an inability to plan ahead, and poor frustration tolerance.Conclusions: The vmPFC has a profound contribution to the development of human prosocial behavior. B.W. demonstrates how a congenital lesion to this cortical region severely disrupts this process.
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U2 - 10.1186/1471-2377-11-151
DO - 10.1186/1471-2377-11-151
M3 - Article
C2 - 22136635
AN - SCOPUS:82455162824
SN - 1471-2377
VL - 11
JO - BMC Neurology
JF - BMC Neurology
M1 - 151
ER -