Barrett's esophagus: Genetic and cell changes

Rhonda F. Souza; Giancarlo Freschi; Antonio Taddei; Maria Novella Ringressi; Paolo Bechi; Francesca Castiglione; Duccio Rossi Degl'Innocenti; George Triadafilopoulos; Jean S. Wang; Andrew C. Chang; Hugh Barr; Manisha Bajpai; Kiron M. Das; Paul M. Schneider; Kausilia K. Krishnadath; Usha Malhotra; John P. Lynch

doi:10.1111/j.1749-6632.2011.06043.x

Barrett's esophagus: Genetic and cell changes

Rhonda F. Souza, Giancarlo Freschi, Antonio Taddei, Maria Novella Ringressi, Paolo Bechi, Francesca Castiglione, Duccio Rossi Degl'Innocenti, George Triadafilopoulos, Jean S. Wang, Andrew C. Chang, Hugh Barr, Manisha Bajpai, Kiron M. Das, Paul M. Schneider, Kausilia K. Krishnadath, Usha Malhotra, John P. Lynch

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The following includes commentaries on how genetic code of Barrett's esophagus (BE) patients, the mechanisms for GERD-induced esophageal expression of caudal homeobox, and the development of Barrett's metaplasia are increasingly better known, including the role of stromal genes in oncogenesis. Additional lessons have been learned fromin vitromodels in nonneoplastic cell lines, yet there are limitations to what can be expected from BE-derived cell lines. Other topics discussed include clonal diversity in Barrett's esophagus; the application of peptide arrays to clinical samples of metaplastic mucosa; proliferation and apoptosis of Barrett's cell lines; tissue biomarkers for neoplasia; and transcription factors associated with BE.

Original language	English (US)
Pages (from-to)	18-35
Number of pages	18
Journal	Annals of the New York Academy of Sciences
Volume	1232
Issue number	1
DOIs	https://doi.org/10.1111/j.1749-6632.2011.06043.x
State	Published - Sep 2011

Keywords

Adenocarcinoma
BAR-T cells
BMP-4
Barrett's esophagus
Bile
CDKN2A
CDX-1gene
CDX-2 gene
Hedgehog pathway
Hox genes
IGF-1R genotype
Intestinal metaplasia
MAb Das-1
Mitogen-activated protein kinase
NF-κB
P16
P53
TP53
Villin

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

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10.1111/j.1749-6632.2011.06043.x

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Souza, R. F., Freschi, G., Taddei, A., Ringressi, M. N., Bechi, P., Castiglione, F., Degl'Innocenti, D. R., Triadafilopoulos, G., Wang, J. S., Chang, A. C., Barr, H., Bajpai, M., Das, K. M., Schneider, P. M., Krishnadath, K. K., Malhotra, U., & Lynch, J. P. (2011). Barrett's esophagus: Genetic and cell changes. Annals of the New York Academy of Sciences, 1232(1), 18-35. https://doi.org/10.1111/j.1749-6632.2011.06043.x

Souza, RF, Freschi, G, Taddei, A, Ringressi, MN, Bechi, P, Castiglione, F, Degl'Innocenti, DR, Triadafilopoulos, G, Wang, JS, Chang, AC, Barr, H, Bajpai, M, Das, KM, Schneider, PM, Krishnadath, KK, Malhotra, U & Lynch, JP 2011, 'Barrett's esophagus: Genetic and cell changes', Annals of the New York Academy of Sciences, vol. 1232, no. 1, pp. 18-35. https://doi.org/10.1111/j.1749-6632.2011.06043.x

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AU - Castiglione, Francesca

AU - Degl'Innocenti, Duccio Rossi

AU - Triadafilopoulos, George

AU - Wang, Jean S.

AU - Chang, Andrew C.

AU - Barr, Hugh

AU - Bajpai, Manisha

AU - Das, Kiron M.

AU - Schneider, Paul M.

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AU - Malhotra, Usha

AU - Lynch, John P.

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Barrett's esophagus: Genetic and cell changes

Abstract

Keywords

ASJC Scopus subject areas

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