TY - JOUR
T1 - Bacterial mechanosensitive channels
T2 - Integrating physiology, structure and function
AU - Blount, Paul
AU - Moe, Paul C.
N1 - Funding Information:
The authors thank Drs I.R. Booth, R. Ranganathan, C. Kung, S.I. Sukharev and A.F. Batiza for helpful discussions and Dr G. Levin and M.J. Richards for critical reading of the manuscript. Our laboratory is supported by Robert A. Welch Foundation Grant I-1420 and American Heart Association Grant 9930193N.
PY - 1999/10/1
Y1 - 1999/10/1
N2 - When confronted with hypo-osmotic stress, many bacterial species are able rapidly to adapt to the increase in cell turgor pressure by jettisoning cytoplasmic solutes into the medium through membrane-tension-gated channels. Physiological studies have confirmed the importance of these channels in osmoregulation. Mutagenesis of one of these channels, combined with structural information derived from X-ray crystallography, has given the first clues of how a mechanosensitive channel senses and responds to membrane tension. Copyright (C) 1999 Elsevier Science Ltd.
AB - When confronted with hypo-osmotic stress, many bacterial species are able rapidly to adapt to the increase in cell turgor pressure by jettisoning cytoplasmic solutes into the medium through membrane-tension-gated channels. Physiological studies have confirmed the importance of these channels in osmoregulation. Mutagenesis of one of these channels, combined with structural information derived from X-ray crystallography, has given the first clues of how a mechanosensitive channel senses and responds to membrane tension. Copyright (C) 1999 Elsevier Science Ltd.
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U2 - 10.1016/S0966-842X(99)01594-2
DO - 10.1016/S0966-842X(99)01594-2
M3 - Review article
C2 - 10498951
AN - SCOPUS:0032844441
SN - 0966-842X
VL - 7
SP - 420
EP - 424
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 10
ER -