Bacterial mechanosensitive channels: Integrating physiology, structure and function

Paul Blount, Paul C. Moe

Research output: Contribution to journalReview articlepeer-review

98 Scopus citations


When confronted with hypo-osmotic stress, many bacterial species are able rapidly to adapt to the increase in cell turgor pressure by jettisoning cytoplasmic solutes into the medium through membrane-tension-gated channels. Physiological studies have confirmed the importance of these channels in osmoregulation. Mutagenesis of one of these channels, combined with structural information derived from X-ray crystallography, has given the first clues of how a mechanosensitive channel senses and responds to membrane tension. Copyright (C) 1999 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)420-424
Number of pages5
JournalTrends in Microbiology
Issue number10
StatePublished - Oct 1 1999

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology


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