TY - JOUR
T1 - Bacteria fighting back
T2 - How pathogens target and subvert the host innate immune system
AU - Reddick, L. Evan
AU - Alto, Neal M.
N1 - Funding Information:
We would like to thank members of the N.M.A. lab for suggestions and insights, especially Maarten F. de Jong, Nikolay Burnaevskiy, and Patrick Woida. We also thank Leonardo D. Estrada for critical reading of the manuscript. This work was supported by grants from the National Institutes of Health (NIAID; 1F32AI098384) to L.E.R. and (NIAID; R01AI083359 and NIGMS; R01GM100486), the Welch Foundation (I-1704), and the Burroughs Wellcome Fund to N.M.A.
PY - 2014/4/24
Y1 - 2014/4/24
N2 - The innate immune system has evolved under selective pressure since the radiation of multicellular life approximately 600 million years ago. Because of this long history, innate immune mechanisms found in modern eukaryotic organisms today are highly complex but yet built from common molecular strategies. It is now clear that evolution has selected a conserved set of antimicrobial peptides as well as pattern-recognition receptors (PRRs) that initiate cellular-based signals as a first line of defense against invading pathogens. Conversely, microbial pathogens employ their own strategies in order to evade, inhibit, or otherwise manipulate the innate immune response. Here, we discuss recent discoveries that have changed our view of immune modulatory mechanisms employed by bacterial pathogens, focusing specifically on the initial sites of microbial recognition and extending to host cellular signal transduction, proinflammatory cytokine production, and alteration of protein trafficking and secretion.
AB - The innate immune system has evolved under selective pressure since the radiation of multicellular life approximately 600 million years ago. Because of this long history, innate immune mechanisms found in modern eukaryotic organisms today are highly complex but yet built from common molecular strategies. It is now clear that evolution has selected a conserved set of antimicrobial peptides as well as pattern-recognition receptors (PRRs) that initiate cellular-based signals as a first line of defense against invading pathogens. Conversely, microbial pathogens employ their own strategies in order to evade, inhibit, or otherwise manipulate the innate immune response. Here, we discuss recent discoveries that have changed our view of immune modulatory mechanisms employed by bacterial pathogens, focusing specifically on the initial sites of microbial recognition and extending to host cellular signal transduction, proinflammatory cytokine production, and alteration of protein trafficking and secretion.
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U2 - 10.1016/j.molcel.2014.03.010
DO - 10.1016/j.molcel.2014.03.010
M3 - Review article
C2 - 24766896
AN - SCOPUS:84899134307
SN - 1097-2765
VL - 54
SP - 321
EP - 328
JO - Molecular cell
JF - Molecular cell
IS - 2
ER -