B cells

Malcolm MacConmara, James A. Lederer

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


We have introduced general ways in which B cells play a role in protective immunity against microbes. Although B cells were originally defined solely as antibody-producing cells, it is now known that they have other functions that are equally as important as producing antibodies. These include antigen-presenting cell activity and the production of natural IgM antibodies that trigger complement activation. Future research will undoubtedly help define how changes in B-cell functions following injury and sepsis affect the development of effective or suppressive immunity in patients who are predisposed to sepsis, are undergoing sepsis, or are in septic shock.

Original languageEnglish (US)
Pages (from-to)S514-S516
JournalCritical care medicine
Issue number12 SUPPL.
StatePublished - Dec 2005

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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