TY - JOUR
T1 - Autosomal dominant neurological disorder
AU - Brady, R. O.
AU - Rosenberg, R. N.
PY - 1978
Y1 - 1978
N2 - Genetic disease in the United States poses an immense problem, with 6% of the population having a genetically related disease, 30% of hospitalized children having a genetically based disorder, and 80% of mental retardation directly due to a genetic entity. In order to develop a general scientific strategy and possible molecular models of dominantly inherited diseases, a symposium was held in Bethesda, MD, on April 6 and 7, 1978. Fifty invited speakers and informal participants considered emerging and established dominantly inherited entities, examined as model approaches disorders in which the molecular pathology is reasonably well understood, considered in detail biochemical implications of genetic patterns, and discussed specific molecular mechanisms that might explain the expression of dominant diseases.
AB - Genetic disease in the United States poses an immense problem, with 6% of the population having a genetically related disease, 30% of hospitalized children having a genetically based disorder, and 80% of mental retardation directly due to a genetic entity. In order to develop a general scientific strategy and possible molecular models of dominantly inherited diseases, a symposium was held in Bethesda, MD, on April 6 and 7, 1978. Fifty invited speakers and informal participants considered emerging and established dominantly inherited entities, examined as model approaches disorders in which the molecular pathology is reasonably well understood, considered in detail biochemical implications of genetic patterns, and discussed specific molecular mechanisms that might explain the expression of dominant diseases.
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U2 - 10.1002/ana.410040612
DO - 10.1002/ana.410040612
M3 - Article
C2 - 33592
AN - SCOPUS:0018251341
SN - 0364-5134
VL - 4
SP - 548
EP - 552
JO - Annals of Neurology
JF - Annals of Neurology
IS - 6
ER -