@article{9e3a0797e06d4d538d683867601ecb53,
title = " Autophagy Regulation of Metabolism Is Required for CD8 + T Cell Anti-tumor Immunity ",
abstract = " DeVorkin et al. show that loss of autophagy enhances CD8 + T-cell-mediated rejection of tumors. Mechanistically, suppression of autophagy shifts T cells to a glycolytic phenotype and causes a reduction in S-adenosylmethionine. As a consequence, autophagy-deficient T cells transcriptionally reprogram immune response genes to an effector memory state.",
keywords = "CD8 T cells, SAM, anti-tumor immunity, autophagy, glycolysis, lactate, methylation",
author = "Lindsay DeVorkin and Nils Pavey and Gillian Carleton and Alexandra Comber and Cally Ho and Junghyun Lim and Erin McNamara and Haochu Huang and Paul Kim and Zacharias, {Lauren G.} and Noboru Mizushima and Tatsuya Saitoh and Shizuo Akira and Wayne Beckham and Alireza Lorzadeh and Michelle Moksa and Qi Cao and Aditya Murthy and Martin Hirst and DeBerardinis, {Ralph J.} and Lum, {Julian J.}",
note = "Funding Information: The authors would like to thank Chris Johnstone and Dr. Magdalena Bazalova-Carter for assistance with radiation of mice to create the bone marrow chimeras, Dr. John Stagg for the e0771 cells, and Dr. Ravi Amaravadi for Lys05. This study was supported by the Canadian Breast Cancer Foundation (J.J.L.), the BC Cancer Foundation (J.J.L.), the Canadian Breast Cancer Foundation Fellowship (L.D.), the Howard Hughes Medical Institute (Faculty Scholars Program; R.J.D.), and the National Cancer Institute (1R35CA22044901; R.J.D.). Conceptualization, L.D. and J.J.L.; Methodology, L.D. N.P. M.H. A.M. and J.J.L.; Investigation, L.D. N.P. G.C. A.C. C.H. P.K. J.L. E.M, H.H, L.G.Z. N.M. T.S. S.A. W.B. A.L. M.M. and Q.C.; Writing – Original Draft and Revisions, all authors; Visualization, L.D. A.C. and J.J.L. Supervision, L.D, A.M. M.H. and J.J.L. Funding Acquisition, L.D and J.J.L. R.J.D. is member of the Scientific Advisory Board at Agios Pharmaceuticals. A.M. J.L. E.M. and H.H. are employees of Genentech Inc. L.D. and J.J.L. are named inventors on a provisional patent related to the research in this manuscript. Funding Information: The authors would like to thank Chris Johnstone and Dr. Magdalena Bazalova-Carter for assistance with radiation of mice to create the bone marrow chimeras, Dr. John Stagg for the e0771 cells, and Dr. Ravi Amaravadi for Lys05. This study was supported by the Canadian Breast Cancer Foundation (J.J.L.), the BC Cancer Foundation (J.J.L.), the Canadian Breast Cancer Foundation Fellowship (L.D.), the Howard Hughes Medical Institute (Faculty Scholars Program; R.J.D.), and the National Cancer Institute ( 1R35CA22044901 ; R.J.D.). Publisher Copyright: {\textcopyright} 2019",
year = "2019",
month = apr,
day = "9",
doi = "10.1016/j.celrep.2019.03.037",
language = "English (US)",
volume = "27",
pages = "502--513.e5",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "2",
}