Autophagy in mammalian antiviral immunity

Anthony Orvedahl; Beth Levine

doi:10.1007/978-3-642-00302-8-13

Autophagy in mammalian antiviral immunity

Anthony Orvedahl, Beth Levine

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Autophagy plays diverse roles in cellular adaptation to stress and promotes vital housekeeping functions by recycling unused or damaged organelles and proteins. As an innate immune defense pathway, autophagy also protects against infection with diverse pathogens, including viruses. Autophagy combats infections with both RNA and DNA viruses, and may function by degrading viral components, by promoting the survival of virally infected cells, and/or by activating innate and adaptive immunity. Viruses have evolved counter-mechanisms to evade host autophagy in order to promote their own survival. This chapter will highlight recent advances and unanswered questions relating to autophagy in mammalian antiviral immunity.

Original language	English (US)
Pages (from-to)	267-285
Number of pages	19
Journal	Current Topics in Microbiology and Immunology
Volume	335
Issue number	1
DOIs	https://doi.org/10.1007/978-3-642-00302-8-13
State	Published - 2009

ASJC Scopus subject areas

Immunology and Allergy
Microbiology (medical)
Immunology
Microbiology

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Autophagy in mammalian antiviral immunity

Abstract

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