Autophagy and the cell biology of age-related disease

Andrew M. Leidal; Beth Levine; Jayanta Debnath

doi:10.1038/s41556-018-0235-8

Autophagy and the cell biology of age-related disease

Andrew M. Leidal, Beth Levine, Jayanta Debnath

Research output: Contribution to journal › Review article › peer-review

280 Scopus citations

Abstract

Macroautophagy (autophagy) is a conserved lysosomal degradation process essential for cellular homeostasis and adaption to stress. Accumulating evidence indicates that autophagy declines with age and that impaired autophagy predisposes individuals to age-related diseases, whereas interventions that stimulate autophagy often promote longevity. In this Review, we examine how the autophagy pathway restricts cellular damage and degeneration, and the impact of these functions towards tissue health and organismal lifespan.

Original language	English (US)
Pages (from-to)	1338-1348
Number of pages	11
Journal	Nature cell biology
Volume	20
Issue number	12
DOIs	https://doi.org/10.1038/s41556-018-0235-8
State	Published - Dec 1 2018

ASJC Scopus subject areas

Cell Biology

Access to Document

10.1038/s41556-018-0235-8

Cite this

@article{e388370db7ad4e1c81be799dbe490b64,

title = "Autophagy and the cell biology of age-related disease",

abstract = "Macroautophagy (autophagy) is a conserved lysosomal degradation process essential for cellular homeostasis and adaption to stress. Accumulating evidence indicates that autophagy declines with age and that impaired autophagy predisposes individuals to age-related diseases, whereas interventions that stimulate autophagy often promote longevity. In this Review, we examine how the autophagy pathway restricts cellular damage and degeneration, and the impact of these functions towards tissue health and organismal lifespan.",

author = "Leidal, {Andrew M.} and Beth Levine and Jayanta Debnath",

note = "Publisher Copyright: {\textcopyright} 2018, Springer Nature Limited.",

year = "2018",

month = dec,

day = "1",

doi = "10.1038/s41556-018-0235-8",

language = "English (US)",

volume = "20",

pages = "1338--1348",

journal = "Nature cell biology",

issn = "1465-7392",

publisher = "Nature Publishing Group",

number = "12",

}

TY - JOUR

T1 - Autophagy and the cell biology of age-related disease

AU - Leidal, Andrew M.

AU - Levine, Beth

AU - Debnath, Jayanta

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Macroautophagy (autophagy) is a conserved lysosomal degradation process essential for cellular homeostasis and adaption to stress. Accumulating evidence indicates that autophagy declines with age and that impaired autophagy predisposes individuals to age-related diseases, whereas interventions that stimulate autophagy often promote longevity. In this Review, we examine how the autophagy pathway restricts cellular damage and degeneration, and the impact of these functions towards tissue health and organismal lifespan.

AB - Macroautophagy (autophagy) is a conserved lysosomal degradation process essential for cellular homeostasis and adaption to stress. Accumulating evidence indicates that autophagy declines with age and that impaired autophagy predisposes individuals to age-related diseases, whereas interventions that stimulate autophagy often promote longevity. In this Review, we examine how the autophagy pathway restricts cellular damage and degeneration, and the impact of these functions towards tissue health and organismal lifespan.

UR - http://www.scopus.com/inward/record.url?scp=85057236648&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057236648&partnerID=8YFLogxK

U2 - 10.1038/s41556-018-0235-8

DO - 10.1038/s41556-018-0235-8

M3 - Review article

C2 - 30482941

AN - SCOPUS:85057236648

SN - 1465-7392

VL - 20

SP - 1338

EP - 1348

JO - Nature cell biology

JF - Nature cell biology

IS - 12

ER -

Autophagy and the cell biology of age-related disease

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this