Autophagy and the cell biology of age-related disease

Andrew M. Leidal, Beth Levine, Jayanta Debnath

Research output: Contribution to journalReview articlepeer-review

268 Scopus citations


Macroautophagy (autophagy) is a conserved lysosomal degradation process essential for cellular homeostasis and adaption to stress. Accumulating evidence indicates that autophagy declines with age and that impaired autophagy predisposes individuals to age-related diseases, whereas interventions that stimulate autophagy often promote longevity. In this Review, we examine how the autophagy pathway restricts cellular damage and degeneration, and the impact of these functions towards tissue health and organismal lifespan.

Original languageEnglish (US)
Pages (from-to)1338-1348
Number of pages11
JournalNature cell biology
Issue number12
StatePublished - Dec 1 2018

ASJC Scopus subject areas

  • Cell Biology


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