TY - JOUR
T1 - Autophagy and Ferroptosis—What Is the Connection?
AU - Kang, Rui
AU - Tang, Daolin
N1 - Funding Information:
Acknowledgments We thank Christine Heiner (Department of Surgery, University of Pittsburgh) for her critical reading of the manuscript. This work was supported by the National Institutes of Health of the USA (R01GM115366 and R01CA160417), the National Natural Science Foundation of China (31671435), the National Natural Science Foundation of Guangdong (2016A030308.), and a Research Scholar Grant from the American Cancer Society (RSG-16-014-01-CDD).
Publisher Copyright:
© 2017, Springer Science+Business Media New York.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Purpose of Review: Autophagy is a conserved intracellular degradation system and plays a dual role in cell death, depending on context and phase. Ferroptosis is a new form of regulated cell death that mainly depends on iron accumulation and lipid peroxidation. In this review, we summarize the processes of autophagy and ferroptosis and discuss their crosstalk mechanisms at the molecular level. Recent Findings: The original study shows that ferroptosis is morphologically, biochemically, and genetically distinct from autophagy and other types of cell death. However, recent studies demonstrate that activation of ferroptosis is indeed dependent on the induction of autophagy. Additionally, many ferroptosis regulators such as SLC7A11, GPX4, NRF2, p53, HSPB1, CISD1, FANCD2, and ACSL4 have been identified as potential regulators of autophagy. Summary: This review not only highlights the importance of autophagy as an emerging mechanism of ferroptosis but also raises new insights regarding regulated cell death.
AB - Purpose of Review: Autophagy is a conserved intracellular degradation system and plays a dual role in cell death, depending on context and phase. Ferroptosis is a new form of regulated cell death that mainly depends on iron accumulation and lipid peroxidation. In this review, we summarize the processes of autophagy and ferroptosis and discuss their crosstalk mechanisms at the molecular level. Recent Findings: The original study shows that ferroptosis is morphologically, biochemically, and genetically distinct from autophagy and other types of cell death. However, recent studies demonstrate that activation of ferroptosis is indeed dependent on the induction of autophagy. Additionally, many ferroptosis regulators such as SLC7A11, GPX4, NRF2, p53, HSPB1, CISD1, FANCD2, and ACSL4 have been identified as potential regulators of autophagy. Summary: This review not only highlights the importance of autophagy as an emerging mechanism of ferroptosis but also raises new insights regarding regulated cell death.
KW - Autophagy
KW - Ferroptosis
KW - Iron metabolism
KW - Lipid peroxidation
KW - Molecular interaction
KW - Signal transduction
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U2 - 10.1007/s40139-017-0139-5
DO - 10.1007/s40139-017-0139-5
M3 - Review article
C2 - 29038744
AN - SCOPUS:85045085246
SN - 2167-485X
VL - 5
SP - 153
EP - 159
JO - Current Pathobiology Reports
JF - Current Pathobiology Reports
IS - 2
ER -