Autonomic dysfunction in multiple sclerosis: Implications for exercise

Mu Huang, Ollie Jay, Scott L. Davis

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


Multiple sclerosis (MS), a progressive neurological disease, can result in autonomic dysfunction. Impairments in the autonomic control of cardiovascular and thermoregulatory function during exercise have been observed in MS. Attenuated elevations in blood pressure during exercise in MS patients can negatively impact blood flow to skeletal muscle. Diminished sweating during exercise may impair heat dissipation likely limiting the exercise intensity that can be performed before detrimental core temperatures are reached. Further understanding the physiologic mechanisms of autonomic dysfunction during exercise in MS may lead to the development of novel therapeutic strategies targeted at improving quality of life in individuals with this disease.

Original languageEnglish (US)
Pages (from-to)82-85
Number of pages4
JournalAutonomic Neuroscience: Basic and Clinical
StatePublished - Mar 1 2015
Externally publishedYes


  • Blood pressure
  • Cardiovascular
  • Demyelination
  • Sweat
  • Sympathetic nerve activity
  • Thermoregulation

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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