TY - JOUR
T1 - Autoimmunity in postural orthostatic tachycardia syndrome
T2 - Current understanding
AU - Vernino, Steven
AU - Stiles, Lauren E.
N1 - Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/12
Y1 - 2018/12
N2 - There is growing interest in the role of autoimmunity in postural orthostatic tachycardia syndrome (POTS). In recent years, investigators have described an increased rate of co-morbid autoimmune disease, and the presence of several neural receptor autoantibodies and non-specific autoimmune markers in POTS. Case reports on the efficacy of immunotherapy in highly selected POTS patients continue to appear in the literature, while no prospective clinical trials have occurred to date. This article summarizes the current state of knowledge on the role of autoimmunity in POTS, the clinical implications of these findings, and prospects for future research.
AB - There is growing interest in the role of autoimmunity in postural orthostatic tachycardia syndrome (POTS). In recent years, investigators have described an increased rate of co-morbid autoimmune disease, and the presence of several neural receptor autoantibodies and non-specific autoimmune markers in POTS. Case reports on the efficacy of immunotherapy in highly selected POTS patients continue to appear in the literature, while no prospective clinical trials have occurred to date. This article summarizes the current state of knowledge on the role of autoimmunity in POTS, the clinical implications of these findings, and prospects for future research.
UR - http://www.scopus.com/inward/record.url?scp=85048402595&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048402595&partnerID=8YFLogxK
U2 - 10.1016/j.autneu.2018.04.005
DO - 10.1016/j.autneu.2018.04.005
M3 - Review article
C2 - 29909990
AN - SCOPUS:85048402595
SN - 1566-0702
VL - 215
SP - 78
EP - 82
JO - Autonomic Neuroscience: Basic and Clinical
JF - Autonomic Neuroscience: Basic and Clinical
ER -