Abstract
Autoantibody testing is integral to the clinical evaluation of suspected autoimmune connective tissue disease, as it aids in disease classification and can sometimes be used to follow disease activity. Autoantibodies are also used in the evaluation of systemic vasculitides. Certain autoantibodies (aAb) have significant disease specificity and thus can be of diagnostic value: anti-dsDNA and -Smith (Sm) aAb for systemic lupus erythematosus; anti-Mi-2, -TIF1-γ, -MDA5, -NXP-2, and -SAE aAb for dermatomyositis; anti-Jo-1 aAb for antisynthetase syndrome; anti-topoisomerase-1 (Scl-70), -RNA polymerase III, and -centromere aAb for different clinical forms of systemic sclerosis; and cytoplasmic anti-neutrophil cytoplasmic antibodies (c-ANCA) for granulomatosis with polyangiitis. However, many aAb are not disease-specific. This chapter also reviews the principles, techniques, and clinical uses of aAb testing.
| Original language | English (US) |
|---|---|
| Title of host publication | Dermatology |
| Subtitle of host publication | Volume 1-2, Fifth Edition |
| Publisher | Elsevier |
| Pages | 657-669 |
| Number of pages | 13 |
| Volume | 1 |
| ISBN (Electronic) | 9780702082252 |
| ISBN (Print) | 9780702084706 |
| DOIs | |
| State | Published - Jan 1 2024 |
Keywords
- ANA
- ANCA
- anti-centromere antibody
- anti-nuclear antibody
- anti-topoisomerase-1 antibody
- antisynthetase syndrome
- autoantibodies
- autoimmune connective tissue disease
- c-ANCA
- dermatomyositis
- p-ANCA
- Scl-70
- systemic lupus erythematosus
- systemic sclerosis
ASJC Scopus subject areas
- General Medicine