Autism and cerebellar dysfunction: Evidence from animal models

Peter T. Tsai

doi:10.1016/j.siny.2016.04.009

Autism and cerebellar dysfunction: Evidence from animal models

Peter T. Tsai

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

Autism is a prevalent neurodevelopmental disorder whose origins are not well understood. Cerebellar involvement has been implicated in the pathogenesis of autism spectrum disorders with increasing evidence from both clinical studies and animal models supporting an important role for cerebellar dysfunction in autism spectrum disorders. This article discusses the various cerebellar contributions to autism spectrum disorders. Both clinical and preclinical studies are discussed and future research directions highlighted.

Original language	English (US)
Pages (from-to)	349-355
Number of pages	7
Journal	Seminars in Fetal and Neonatal Medicine
Volume	21
Issue number	5
DOIs	https://doi.org/10.1016/j.siny.2016.04.009
State	Published - Oct 1 2016

Keywords

Animal models
Autism spectrum disorders
Cerebellum
Circuitry
Critical periods

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/j.siny.2016.04.009

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abstract = "Autism is a prevalent neurodevelopmental disorder whose origins are not well understood. Cerebellar involvement has been implicated in the pathogenesis of autism spectrum disorders with increasing evidence from both clinical studies and animal models supporting an important role for cerebellar dysfunction in autism spectrum disorders. This article discusses the various cerebellar contributions to autism spectrum disorders. Both clinical and preclinical studies are discussed and future research directions highlighted.",

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AB - Autism is a prevalent neurodevelopmental disorder whose origins are not well understood. Cerebellar involvement has been implicated in the pathogenesis of autism spectrum disorders with increasing evidence from both clinical studies and animal models supporting an important role for cerebellar dysfunction in autism spectrum disorders. This article discusses the various cerebellar contributions to autism spectrum disorders. Both clinical and preclinical studies are discussed and future research directions highlighted.

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KW - Cerebellum

KW - Circuitry

KW - Critical periods

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Autism and cerebellar dysfunction: Evidence from animal models

Abstract

Keywords

ASJC Scopus subject areas

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