TY - JOUR
T1 - Auditory steady-state EEG response across the schizo-bipolar spectrum
AU - Parker, David A.
AU - Hamm, Jordan P.
AU - McDowell, Jennifer E.
AU - Keedy, Sarah K.
AU - Gershon, Elliot S.
AU - Ivleva, Elena I.
AU - Pearlson, Godfrey D.
AU - Keshavan, Matcheri S.
AU - Tamminga, Carol A.
AU - Sweeney, John A.
AU - Clementz, Brett A.
N1 - Funding Information:
National Institutes of Health, National Institute of Mental Health (NIMH): MH096942, MH078113, MH096900, MH103366, MH096913, MH077851, MH096957, MH077945, MH103368. The authors thank Francis Kittle, Brad Witte, and Gaurav Poudyal for their contributions to data management and organization. They thank the numerous researchers and clinicians who assisted in recruitment and data collection. Most importantly, they express gratitude to the patients who contributed their time and effort to participate in this study.
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/7
Y1 - 2019/7
N2 - Deviant auditory steady-state responses (aSSRs) in the gamma range (30–90 Hz) may be translational biomarkers for schizophrenia (SZ). This study tests whether aSSR deviations are (i) specific to SZ across the psychosis dimension, (ii) specific to particular frequency bands, and (iii) present in bipolar I disorder without psychosis (BDNP). Methods: Beta (20-), low- (40-), and high-gamma (80-Hz) aSSRs were measured with EEG and compared across 113 SZ, 105 schizoaffective disorder (SAD), 99 bipolar disorder with psychosis (BDP), 68 BDNP, and 137 healthy comparison subjects (HC). Standard aSSR measures (single-trial power [STP] and inter-trial phase coherence [ITC]), as well as evoked responses to stimulus onsets/offsets and pre-stimulus power, were quantified. Multivariate canonical discriminant analysis was used to summarize variables that efficiently and maximally differentiated groups. Results: (i) Psychosis groups showed reduced responses on ITC 20 Hz, STP/ITC 40 Hz, STP/ITC 80 Hz, indicating dimensional reductions in aSSR across the psychosis spectrum not specific to aSSR frequency. For the 40- and 80-Hz ITCs there was greater reduction in SZ compared to SAD, possibly indexing cortical disruptions linked to psychosis without mood symptoms. (ii) All probands had elevated pre-stimulus power, possibly compromising neural entrainment to the steady-state stimuli. (iii) Onset/Offset and 80 Hz ITC responses were most important for group discrimination and showed dimensional reduction across the schizo-bipolar spectrum. Conclusions: Deviant aSSRs were found across the schizo-bipolar spectrum at multiple frequencies with psychosis status and severity linked to greatest reductions at low and high gamma.
AB - Deviant auditory steady-state responses (aSSRs) in the gamma range (30–90 Hz) may be translational biomarkers for schizophrenia (SZ). This study tests whether aSSR deviations are (i) specific to SZ across the psychosis dimension, (ii) specific to particular frequency bands, and (iii) present in bipolar I disorder without psychosis (BDNP). Methods: Beta (20-), low- (40-), and high-gamma (80-Hz) aSSRs were measured with EEG and compared across 113 SZ, 105 schizoaffective disorder (SAD), 99 bipolar disorder with psychosis (BDP), 68 BDNP, and 137 healthy comparison subjects (HC). Standard aSSR measures (single-trial power [STP] and inter-trial phase coherence [ITC]), as well as evoked responses to stimulus onsets/offsets and pre-stimulus power, were quantified. Multivariate canonical discriminant analysis was used to summarize variables that efficiently and maximally differentiated groups. Results: (i) Psychosis groups showed reduced responses on ITC 20 Hz, STP/ITC 40 Hz, STP/ITC 80 Hz, indicating dimensional reductions in aSSR across the psychosis spectrum not specific to aSSR frequency. For the 40- and 80-Hz ITCs there was greater reduction in SZ compared to SAD, possibly indexing cortical disruptions linked to psychosis without mood symptoms. (ii) All probands had elevated pre-stimulus power, possibly compromising neural entrainment to the steady-state stimuli. (iii) Onset/Offset and 80 Hz ITC responses were most important for group discrimination and showed dimensional reduction across the schizo-bipolar spectrum. Conclusions: Deviant aSSRs were found across the schizo-bipolar spectrum at multiple frequencies with psychosis status and severity linked to greatest reductions at low and high gamma.
KW - Auditory steady-state response
KW - Bipolar disorder
KW - EEG biomarkers
KW - Gamma oscillations
KW - Psychosis
KW - Schizophrenia
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U2 - 10.1016/j.schres.2019.04.014
DO - 10.1016/j.schres.2019.04.014
M3 - Article
C2 - 31080153
AN - SCOPUS:85065229547
SN - 0920-9964
VL - 209
SP - 218
EP - 226
JO - Schizophrenia Research
JF - Schizophrenia Research
ER -