TY - JOUR
T1 - Atpenins, new antifungal antibiotics produced by penicillium sp. Production, isolation, physico-chemical and biological properties
AU - Omura, S.
AU - Tomoda, H.
AU - Kimura, K.
AU - Zhen, D. Z.
AU - Kumagai, H.
AU - Igarashi, K.
AU - Imamura, N.
AU - Takahashi, Y.
AU - Tanaka, Y.
AU - Iwai, Y.
PY - 1988
Y1 - 1988
N2 - Penidllium sp. FO-125, a soil isolate, was found to produce a new antifungal antibiotic complex named atpenin. Three components A4, A5 and B were isolated from the fermentation broth of the producing strain by solvent extraction, silica gel column chromatography and HPLC. The molecular formula of atpenins A4, A5 and B were determined to be C15H22NO5Cl, C15H21NO5Cl2 and C15H23NO5, respectively, on the basis of high resolution electron impact mass spectrometry and elemental analysis. They are active against filamentous fungi, especially, Trichophyton sp.
AB - Penidllium sp. FO-125, a soil isolate, was found to produce a new antifungal antibiotic complex named atpenin. Three components A4, A5 and B were isolated from the fermentation broth of the producing strain by solvent extraction, silica gel column chromatography and HPLC. The molecular formula of atpenins A4, A5 and B were determined to be C15H22NO5Cl, C15H21NO5Cl2 and C15H23NO5, respectively, on the basis of high resolution electron impact mass spectrometry and elemental analysis. They are active against filamentous fungi, especially, Trichophyton sp.
UR - http://www.scopus.com/inward/record.url?scp=0024261679&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024261679&partnerID=8YFLogxK
U2 - 10.7164/antibiotics.41.1769
DO - 10.7164/antibiotics.41.1769
M3 - Article
C2 - 3209470
AN - SCOPUS:0024261679
SN - 0021-8820
VL - 41
SP - 1769
EP - 1773
JO - The Journal of Antibiotics
JF - The Journal of Antibiotics
IS - 12
ER -