Asymmetric total synthesis of (+)-fostriecin

Y. Krishna Reddy; J R Falck

doi:10.1021/ol025537r

Asymmetric total synthesis of (+)-fostriecin

Y. Krishna Reddy, J R Falck

Biochemistry

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

(equation presented) The title compound, a potent protein phosphatase inhibitor and anticancer agent, was prepared by an efficient, multiconvergent asymmetric synthesis. Key transformations include a ring forming olefin metathesis leading to the α,β-unsaturated lactone and creation of the triene moiety via Suzuki cross-coupling.

Original language	English (US)
Pages (from-to)	969-971
Number of pages	3
Journal	Organic Letters
Volume	4
Issue number	6
DOIs	https://doi.org/10.1021/ol025537r
State	Published - Mar 21 2002

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol025537r

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title = "Asymmetric total synthesis of (+)-fostriecin",

abstract = "(equation presented) The title compound, a potent protein phosphatase inhibitor and anticancer agent, was prepared by an efficient, multiconvergent asymmetric synthesis. Key transformations include a ring forming olefin metathesis leading to the α,β-unsaturated lactone and creation of the triene moiety via Suzuki cross-coupling.",

author = "Reddy, {Y. Krishna} and Falck, {J R}",

year = "2002",

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day = "21",

doi = "10.1021/ol025537r",

language = "English (US)",

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journal = "Organic Letters",

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AU - Reddy, Y. Krishna

AU - Falck, J R

PY - 2002/3/21

Y1 - 2002/3/21

N2 - (equation presented) The title compound, a potent protein phosphatase inhibitor and anticancer agent, was prepared by an efficient, multiconvergent asymmetric synthesis. Key transformations include a ring forming olefin metathesis leading to the α,β-unsaturated lactone and creation of the triene moiety via Suzuki cross-coupling.

AB - (equation presented) The title compound, a potent protein phosphatase inhibitor and anticancer agent, was prepared by an efficient, multiconvergent asymmetric synthesis. Key transformations include a ring forming olefin metathesis leading to the α,β-unsaturated lactone and creation of the triene moiety via Suzuki cross-coupling.

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DO - 10.1021/ol025537r

M3 - Article

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SP - 969

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JO - Organic Letters

JF - Organic Letters

IS - 6

ER -

Asymmetric total synthesis of (+)-fostriecin

Abstract

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