Asthma treatment in pregnancy: A randomized controlled study

P. J. Wendel, S. M. Ramin, C. Barnett-Hamm, T. F. Rowe, F. G. Cunningham

Research output: Contribution to journalArticlepeer-review

130 Scopus citations


OBJECTIVE: Our purpose was to study the effect of inhaled corticosteroids on asthma exacerbations in pregnancy. STUDY DESIGN: We prospectively studied 84 pregnant women with 105 asthma exacerbations. Women were hospitalized if the forced expiratory volume in 1 second was <70% after sequential bronchodilator therapy. They were randomly assigned to receive either intravenous aminophylline and inhaled β2-adrenergic receptor agonist or intravenous methylprednisolone and a β2-adrenergic receptor agonist. At discharge women were randomly assigned to receive either inhaled beclomethasone, β2-adrenergic receptor agonist, and an oral corticosteroid taper or a β2-adrenergic receptor agonist and a corticosteroid taper. RESULTS: Sixty-five (62%) of 105 women with exacerbation required hospitalization. Aminophylline did not shorten response time or decrease hospital stay. Readmission rate was decreased by 55% in women given inhaled beclomethasone (33% vs 12%, p < 0.05, odds ratio 3.63, 95% confidence interval 1.01 to 13.08). Pregnancy-induced hypertension and cesarean delivery were increased over those of the general population. CONCLUSIONS: Intravenous aminophylline offers no therapeutic advantages. Continuous inhaled corticosteroids reduced the need for subsequent admissions.

Original languageEnglish (US)
Pages (from-to)150-154
Number of pages5
JournalAmerican journal of obstetrics and gynecology
Issue number1
StatePublished - Jan 1 1996


  • Asthma
  • aminophylline
  • inhaled corticosteroids

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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