Asthma: The Interplay Between Viral Infections and Allergic Diseases

Regina K. Rowe; Michelle A. Gill

doi:10.1016/j.iac.2014.09.012

Asthma: The Interplay Between Viral Infections and Allergic Diseases

Regina K. Rowe, Michelle A. Gill

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

Respiratory viruses and allergens synergistically contribute to disease pathogenesis in asthma. Potential mechanisms underlying this clinically relevant association are the subject of intense investigation. This review summarizes current knowledge and recent advances in this area, with an emphasis on potential mechanisms involving immunoglobulin E, type I interferon antiviral responses, epithelial factors, and the role of dendritic cells and other antigen-presenting cells in linking viral and allergic inflammatory responses relevant to asthmatic disease.

Original language	English (US)
Pages (from-to)	115-127
Number of pages	13
Journal	Immunology and Allergy Clinics of North America
Volume	35
Issue number	1
DOIs	https://doi.org/10.1016/j.iac.2014.09.012
State	Published - 2015

Keywords

Allergy
Asthma
Atopy
Dendritic cells
Immunoglobulin E
Rhinovirus
Type I interferon
Viral infection

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.iac.2014.09.012

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title = "Asthma: The Interplay Between Viral Infections and Allergic Diseases",

abstract = "Respiratory viruses and allergens synergistically contribute to disease pathogenesis in asthma. Potential mechanisms underlying this clinically relevant association are the subject of intense investigation. This review summarizes current knowledge and recent advances in this area, with an emphasis on potential mechanisms involving immunoglobulin E, type I interferon antiviral responses, epithelial factors, and the role of dendritic cells and other antigen-presenting cells in linking viral and allergic inflammatory responses relevant to asthmatic disease.",

keywords = "Allergy, Asthma, Atopy, Dendritic cells, Immunoglobulin E, Rhinovirus, Type I interferon, Viral infection",

author = "Rowe, {Regina K.} and Gill, {Michelle A.}",

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year = "2015",

doi = "10.1016/j.iac.2014.09.012",

language = "English (US)",

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pages = "115--127",

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AU - Rowe, Regina K.

AU - Gill, Michelle A.

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N2 - Respiratory viruses and allergens synergistically contribute to disease pathogenesis in asthma. Potential mechanisms underlying this clinically relevant association are the subject of intense investigation. This review summarizes current knowledge and recent advances in this area, with an emphasis on potential mechanisms involving immunoglobulin E, type I interferon antiviral responses, epithelial factors, and the role of dendritic cells and other antigen-presenting cells in linking viral and allergic inflammatory responses relevant to asthmatic disease.

AB - Respiratory viruses and allergens synergistically contribute to disease pathogenesis in asthma. Potential mechanisms underlying this clinically relevant association are the subject of intense investigation. This review summarizes current knowledge and recent advances in this area, with an emphasis on potential mechanisms involving immunoglobulin E, type I interferon antiviral responses, epithelial factors, and the role of dendritic cells and other antigen-presenting cells in linking viral and allergic inflammatory responses relevant to asthmatic disease.

KW - Allergy

KW - Asthma

KW - Atopy

KW - Dendritic cells

KW - Immunoglobulin E

KW - Rhinovirus

KW - Type I interferon

KW - Viral infection

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SN - 0889-8561

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JO - Immunology and Allergy Clinics of North America

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IS - 1

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Asthma: The Interplay Between Viral Infections and Allergic Diseases

Abstract

Keywords

ASJC Scopus subject areas

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