TY - JOUR
T1 - Associations between three-dimensional measurements of the spinal deformity and preoperative SRS-22 scores in patients undergoing surgery for major thoracic adolescent idiopathic scoliosis
AU - the Harms Study Group
AU - Ohashi, Masayuki
AU - Bastrom, Tracey P.
AU - Bartley, Carrie E.
AU - Yaszay, Burt
AU - Upasani, Vidyadhar V.
AU - Newton, Peter O.
AU - Buckland, Aaron
AU - Samdani, Amer
AU - Jain, Amit
AU - Lonner, Baron
AU - Roye, Benjamin
AU - Reilly, Chris
AU - Hedequist, Daniel
AU - Sucato, Daniel
AU - Clements, David
AU - Miyanji, Firoz
AU - Shufflebarger, Harry
AU - Flynn, Jack
AU - Asghar, Jahangir
AU - Thiong, Jean Marc Mac
AU - Pahys, Joshua
AU - Harms, Juergen
AU - Bachmann, Keith
AU - Lenke, Larry
AU - Abel, Mark
AU - Glotzbecker, Michael
AU - Kelly, Michael
AU - Vitale, Michael
AU - Marks, Michelle
AU - Gupta, Munish
AU - Fletcher, Nicholas
AU - Cahill, Patrick
AU - Sponseller, Paul
AU - Gabos, Peter
AU - Sturm, Peter
AU - Betz, Randal
AU - Lehman, Ron
AU - Parent, Stefan
AU - George, Stephen
AU - Hwang, Steven
AU - Shah, Suken
AU - Errico, Tom
AU - Upasani, Vidyadhar
N1 - Funding Information:
Funding was provided by Setting Scoliosis Straight Foundation. Acknowledgements
Funding Information:
Funding to support this study was received from the Rady Children’s Hospital Assaraf Family. Fund and from research grants to Setting Scoliosis Straight Foundation from DePuy Synthes. Spine, EOS imaging, K2M, Medtronic, NuVasive and Zimmer Biomet in support of Harms. Study Group research. Harms Study Group Investigators: Aaron Buckland, MD; New York University Amer Samdani, MD; Shriners Hospitals for Children—Philadelphia, Amit Jain, MD; Johns Hopkins Hospital, Baron Lonner, MD; Mount Sinai Hospital, Benjamin Roye, MD; Columbia University, Burt Yaszay, MD; Rady Children’s Hospital, Chris Reilly, MD; BC Children’s Hospital, Daniel Hedequist, MD; Boston Children’s Hospital, Daniel Sucato, MD; Texas Scottish Rite Hospital, David Clements, MD; Cooper Bone & Joint Institute New Jersey. Title Page: Firoz Miyanji, MD; BC Children’s Hospital, Harry Shufflebarger, MD; Nicklaus Children's Hospital, Jack Flynn, MD; Children’s Hospital of Philadelphia, Jahangir Asghar, MD; Cantor Spine Institute, Jean Marc Mac Thiong, MD; CHU Sainte-Justine, Joshua Pahys, MD; Shriners Hospitals for Children—Philadelphia, Juergen Harms, MD; Klinikum Karlsbad-Langensteinbach, Karlsbad, Keith Bachmann, MD; University of Virginia, Larry Lenke, MD; Columbia University, Mark Abel, MD; University of Virginia, Michael Glotzbecker, MD; Boston Children’s Hospital, Michael Kelly, MD; Washington University, Michael Vitale, MD; Columbia University, Michelle Marks, PT, MA; Setting Scoliosis Straight Foundation, Munish Gupta, MD; Washington University, Nicholas Fletcher, MD; Emory University, Patrick Cahill, MD; Children’s Hospital of Philadelphia, Paul Sponseller, MD; Johns Hopkins Hospital, Peter Gabos, MD: Nemours/Alfred I. duPont Hospital for Children, Peter Newton, MD; Rady Children’s Hospital, Peter Sturm, MD; Cincinnati Children’s Hospital, Randal Betz, MD; Institute for Spine & Scoliosis, Ron Lehman, MD; Columbia University, Stefan Parent, MD: CHU Sainte-Justine, Stephen George, MD; Nicklaus Children's Hospital, Steven Hwang, MD; Shriners Hospitals for Children—Philadelphia, Suken Shah, MD; Nemours/Alfred I. duPont Hospital for Children, Tom Errico, MD; Nicklaus Children's Hospital, Vidyadhar Upasani, MD; Rady Children’s Hospital.
Funding Information:
Funding to support this study was received from the Rady Children’s Hospital Assaraf Family. Fund and from research grants to Setting Scoliosis Straight Foundation from DePuy Synthes. Spine, EOS imaging, K2M, Medtronic, NuVasive and Zimmer Biomet in support of Harms. Study Group research.
Publisher Copyright:
© 2020, Scoliosis Research Society.
PY - 2020/12
Y1 - 2020/12
N2 - Study design: Retrospective study. Objective: To analyze the relationships between three-dimensional (3D) measurements of spinal deformity and Scoliosis Research Society-22 (SRS-22) scores in preoperative patients with major thoracic adolescent idiopathic scoliosis (AIS). Summary and background data: Previous studies reported 2D measurements were not or only weakly correlated with preoperative SRS-22 scores. However, 2D measures do not always accurately represent the 3D deformity. Methods: A multicenter prospective registry of surgically treated AIS patients was reviewed for patients with right major thoracic AIS (Lenke type 1–4) who underwent biplanar radiography and completed the SRS-22 questionnaire preoperatively. For the 3D measurements, two reference frames were utilized: global (gravity/patient-based) and local (vertebra/disc-based). To obtain regional measurements, the individual segments in the appropriate reference plane were summed between the levels of interest. Patients were divided into two groups for each SRS-22 domain according to their scores: low (< 4) and high (≥ 4) score groups. Group differences and correlations with SRS-22 scores were analyzed with p < 0.01 as the threshold for significance. Results: There were 405 eligible patients (mean age, 14.4 years). The mean 3D thoracic curve was 59° (45°–115°). The only significant group difference of 3D measurements occurred in the local lumbar lordosis (LL) with a small mean difference (− 3.4°, p = 0.008) in the mental health domain. In the correlation analyses, global and local thoracic kyphosis (TK) and TK/LL ratio demonstrated significant, but weak, correlations with function and total scores (|r|< 0.2, p < 0.01). Conclusion: 3D measurements of scoliosis severity have only weak associations with preoperative SRS-22 scores, which might indicate a limit to the discriminative capacity of the SRS-22 within surgical range major thoracic AIS curves. Interestingly, the sagittal plane was the principle 3D plane in which significant correlations existed. Level of evidence: II, prognostic.
AB - Study design: Retrospective study. Objective: To analyze the relationships between three-dimensional (3D) measurements of spinal deformity and Scoliosis Research Society-22 (SRS-22) scores in preoperative patients with major thoracic adolescent idiopathic scoliosis (AIS). Summary and background data: Previous studies reported 2D measurements were not or only weakly correlated with preoperative SRS-22 scores. However, 2D measures do not always accurately represent the 3D deformity. Methods: A multicenter prospective registry of surgically treated AIS patients was reviewed for patients with right major thoracic AIS (Lenke type 1–4) who underwent biplanar radiography and completed the SRS-22 questionnaire preoperatively. For the 3D measurements, two reference frames were utilized: global (gravity/patient-based) and local (vertebra/disc-based). To obtain regional measurements, the individual segments in the appropriate reference plane were summed between the levels of interest. Patients were divided into two groups for each SRS-22 domain according to their scores: low (< 4) and high (≥ 4) score groups. Group differences and correlations with SRS-22 scores were analyzed with p < 0.01 as the threshold for significance. Results: There were 405 eligible patients (mean age, 14.4 years). The mean 3D thoracic curve was 59° (45°–115°). The only significant group difference of 3D measurements occurred in the local lumbar lordosis (LL) with a small mean difference (− 3.4°, p = 0.008) in the mental health domain. In the correlation analyses, global and local thoracic kyphosis (TK) and TK/LL ratio demonstrated significant, but weak, correlations with function and total scores (|r|< 0.2, p < 0.01). Conclusion: 3D measurements of scoliosis severity have only weak associations with preoperative SRS-22 scores, which might indicate a limit to the discriminative capacity of the SRS-22 within surgical range major thoracic AIS curves. Interestingly, the sagittal plane was the principle 3D plane in which significant correlations existed. Level of evidence: II, prognostic.
KW - Adolescent idiopathic scoliosis
KW - Outcome measures
KW - Quality of life
KW - SRS-22
KW - Three-dimensional measurement
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U2 - 10.1007/s43390-020-00150-0
DO - 10.1007/s43390-020-00150-0
M3 - Article
C2 - 32488765
AN - SCOPUS:85086031323
SN - 2212-134X
VL - 8
SP - 1253
EP - 1260
JO - Spine deformity
JF - Spine deformity
IS - 6
ER -