Association of β-Lactam Allergy Documentation and Prophylactic Antibiotic Use in Surgery: A National Cross-Sectional Study of Hospitalized Patients

Christie M. Bertram; Michael Postelnick; Christian M. Mancini; Xiaoqing Fu; Yuqing Zhang; Lucas T. Schulz; Tanaya Bhowmick; Francesca Lee; Kimberly G. Blumenthal

doi:10.1093/cid/ciaa1762

Association of β-Lactam Allergy Documentation and Prophylactic Antibiotic Use in Surgery: A National Cross-Sectional Study of Hospitalized Patients

Christie M. Bertram, Michael Postelnick, Christian M. Mancini, Xiaoqing Fu, Yuqing Zhang, Lucas T. Schulz, Tanaya Bhowmick, Francesca Lee, Kimberly G. Blumenthal

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Alternative antibiotics for surgical prophylaxis are associated with increased adverse events and surgical site infection compared to cefazolin. In a sample of perioperative inpatients from 100 hospitals in the United States, cefazolin was 9-fold less likely to be used in patients with a documented β-lactam allergy whereas clindamycin was 45-fold more likely.

Original language	English (US)
Pages (from-to)	E872-E875
Journal	Clinical Infectious Diseases
Volume	72
Issue number	11
DOIs	https://doi.org/10.1093/cid/ciaa1762
State	Published - Jun 1 2021

Keywords

allergy
antibiotic
surgical prophylaxis
β-lactam

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1093/cid/ciaa1762

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title = "Association of β-Lactam Allergy Documentation and Prophylactic Antibiotic Use in Surgery: A National Cross-Sectional Study of Hospitalized Patients",

abstract = "Alternative antibiotics for surgical prophylaxis are associated with increased adverse events and surgical site infection compared to cefazolin. In a sample of perioperative inpatients from 100 hospitals in the United States, cefazolin was 9-fold less likely to be used in patients with a documented β-lactam allergy whereas clindamycin was 45-fold more likely.",

keywords = "allergy, antibiotic, surgical prophylaxis, β-lactam",

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AU - Postelnick, Michael

AU - Mancini, Christian M.

AU - Fu, Xiaoqing

AU - Zhang, Yuqing

AU - Schulz, Lucas T.

AU - Bhowmick, Tanaya

AU - Lee, Francesca

AU - Blumenthal, Kimberly G.

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N2 - Alternative antibiotics for surgical prophylaxis are associated with increased adverse events and surgical site infection compared to cefazolin. In a sample of perioperative inpatients from 100 hospitals in the United States, cefazolin was 9-fold less likely to be used in patients with a documented β-lactam allergy whereas clindamycin was 45-fold more likely.

AB - Alternative antibiotics for surgical prophylaxis are associated with increased adverse events and surgical site infection compared to cefazolin. In a sample of perioperative inpatients from 100 hospitals in the United States, cefazolin was 9-fold less likely to be used in patients with a documented β-lactam allergy whereas clindamycin was 45-fold more likely.

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KW - surgical prophylaxis

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Association of β-Lactam Allergy Documentation and Prophylactic Antibiotic Use in Surgery: A National Cross-Sectional Study of Hospitalized Patients

Abstract

Keywords

ASJC Scopus subject areas

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