Association of triglyceride-to-high density lipoprotein cholesterol ratio to cardiorespiratory fitness in men

Gloria L Vega, Scott M Grundy, Carolyn E. Barlow, David Leonard, Benjamin L. Willis, Laura F. DeFina, Stephen W. Farrell

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Background Both triglyceride-to-high density lipoprotein cholesterol (TG/HDL-C) and cardiorespiratory fitness (CRF) impart risk for all-cause morbidity and mortality independently of conventional risk factors. Objective To determine prevalence and/or incidence of high TG/HDL-C ratio in men with low CRF. Methods Clinical characteristics and CRF were used to determine prevalence of a TG/HDL-C ratio ≥ 3.5 (high ratio) in 13,954 men of the Cooper Center Longitudinal Study. High-ratio conversion was determined in 10,424 men with normal baseline TG/HDL-C ratio. Hazard ratio (HR) of incident high TG/HDL-C was adjusted for age and waist girth. Results Men with low CRF had the highest prevalence of a high TG/HDL-C ratio. In the population with normal TG/HDL-C, age-adjusted HR of incident high TG/HDL-C ratio was 2.77 times higher in men with lowest CRF than in those with highest CRF. Incidence of conversion of normal to high ratio was 5.5% per year in low CRF population, compared with 1.7% in high CRF subjects. Incidence HR was independent of waist girth. Men who converted from normal to high TG/HDL-C ratio during the follow-up period had increased number of metabolic risk factors and a higher prevalence of metabolic syndrome. Men who did not convert to a high TG/HDL-C ratio retained a low prevalence of metabolic syndrome risk factors. Conclusion A high TG/HDL-C ratio is common in men with low CRF. Metabolic syndrome also is common among those with a high ratio.

Original languageEnglish (US)
Pages (from-to)1414-1422.e1
JournalJournal of Clinical Lipidology
Issue number6
StatePublished - Nov 1 2016


  • Cardiorespiratory fitness
  • TG/HDL-C ratio

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine


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