@article{1938e9c579964bf5bc74860d7baa1092,
title = "Association of Placental Pathologic Findings with the Severity of Necrotizing Enterocolitis in Preterm infants–A Matched Case-Control Study",
abstract = "Objective: To determine the association of placental pathology with the severity of necrotizing enterocolitis (NEC) in preterm infants. Methods: This single-center matched case-control study included infants with NEC (n = 107) and gestational age and birth weight-matched controls (n = 130), born between 2013 and 2020. Placentas were evaluated according to the Amsterdam Placental Workshop Group Consensus Statement. Results: Acute histologic chorioamnionitis with the fetal response was significantly more common in infants with surgical NEC vs. medical NEC (35.4% vs. 15.3%; p = 0.02). On regression model, infants with multiple placental pathologies (OR 2.16; 95% CI 1.01 − 4.73; p = 0.04) and maternal vascular malperfusion (OR 2.2; 95% CI 1.12 − 4.51; p = 0.02) had higher odds of either medical or surgical NEC than controls. Conclusion: Infants with multiple placental lesions, including placental inflammatory and vascular lesions, were at higher risk of medical or surgical NEC in the postnatal period.",
keywords = "Necrotizing enterocolitis, placental pathology, preterm infants",
author = "Garg, {Parvesh Mohan} and Paschal, {Jaslyn L.} and Ansari, {Md Abu Yusuf} and Lauren Billington and Jennifer Ware and Kristin Adams and Hamda, {Youssef Al} and Adebamike Oshunbade and Rosenfeld, {Charles R.} and Mir, {Imran N.}",
note = "Funding Information: Dr. Parvesh Garg is partially supported by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number 5U54GM115428. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This work was also supported by {\textquoteleft}2020 Children{\textquoteright}s Clinical Research Advisory Committee (CCRAC) Research Grant{\textquoteright}, awarded to Dr. Imran Mir. The Mississippi Clinical and Translational Center (MCCTR) for supporting the NEC research. We would like to thank Dr. Redline from Case Western University and Dr. Suhas G. Kallapur from UCLA Mattel Children{\textquoteright}s Hospital for all the guidance for the project. We would also like to thank the Mississippi Center for Clinical/Translational Research for supporting the N.E.C. research. Publisher Copyright: {\textcopyright} 2022 Taylor & Francis Group, LLC.",
year = "2023",
doi = "10.1080/15513815.2022.2110340",
language = "English (US)",
volume = "42",
pages = "187--197",
journal = "Fetal and Pediatric Pathology",
issn = "1551-3815",
publisher = "Informa Healthcare",
number = "2",
}