Association of maternal pre-pregnancy or first trimester body mass index with neurodevelopmental impairment or death in extremely low gestational age neonates

Sanjay Chawla; Abbot R. Laptook; Emily A. Smith; Sylvia Tan; Girija Natarajan; Myra H. Wyckoff; Rachel G. Greenberg; Namasivayam Ambalavanan; Edward F. Bell; Krisa P. Van Meurs; Susan R. Hintz; Betty R. Vohr; Erika F. Werner; Abhik Das; Seetha Shankaran; Waldemar A. Carlo; Anna Maria Hibbs; Stephanie Merhar; C. Michael Cotten; Ravi M. Patel; Tarah T. Colaizy; Aaron Hamvas; Abhay J. Bhatt; Janell Fuller; Sara DeMauro; Anup C. Katheria; Robin K. Ohls; Jon E. Tyson

doi:10.1038/s41372-024-01905-7

Association of maternal pre-pregnancy or first trimester body mass index with neurodevelopmental impairment or death in extremely low gestational age neonates

Sanjay Chawla, Abbot R. Laptook, Emily A. Smith, Sylvia Tan, Girija Natarajan, Myra H. Wyckoff, Rachel G. Greenberg, Namasivayam Ambalavanan, Edward F. Bell, Krisa P. Van Meurs, Susan R. Hintz, Betty R. Vohr, Erika F. Werner, Abhik Das, Seetha Shankaran, Waldemar A. Carlo, Anna Maria Hibbs, Stephanie Merhar, C. Michael Cotten, Ravi M. PatelTarah T. Colaizy, Aaron Hamvas, Abhay J. Bhatt, Janell Fuller, Sara DeMauro, Anup C. Katheria, Robin K. Ohls, Jon E. Tyson

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To compare the rates of death or survival with severe neurodevelopmental impairment (sNDI) at 2 years among extremely preterm infants in relation to pre-pregnancy or first-trimester maternal body mass index (BMI). Methods: This retrospective cohort study included extremely preterm infants (gestational age 22^0/7–26^6/7 weeks). The study was conducted at National Institute of Child Health and Human Development Neonatal Research Network sites. The primary outcome was death or sNDI at 2 years. Results: Data on the primary outcome were available for 1208 children. Death or sNDI was not different among the three groups: 54.9% in normal, 56.1% in overweight, and 53.4% in obese group (p = 0.39). There was no significant difference in mortality, sNDI, moderate/severe cerebral palsy, Bayley Scales of Infant Development (BSID)-III cognitive composite score <70, BSID-III language composite score <70 in adjusted models. Conclusion: Neurodevelopmental outcome was not significantly associated with maternal pre-pregnancy BMI among extreme preterm infants.

Original language	English (US)
Pages (from-to)	802-810
Number of pages	9
Journal	Journal of Perinatology
Volume	44
Issue number	6
DOIs	https://doi.org/10.1038/s41372-024-01905-7
State	Published - Jun 2024

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1038/s41372-024-01905-7

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Chawla, S., Laptook, A. R., Smith, E. A., Tan, S., Natarajan, G., Wyckoff, M. H., Greenberg, R. G., Ambalavanan, N., Bell, E. F., Van Meurs, K. P., Hintz, S. R., Vohr, B. R., Werner, E. F., Das, A., Shankaran, S., Carlo, W. A., Hibbs, A. M., Merhar, S., Cotten, C. M., ... Tyson, J. E. (2024). Association of maternal pre-pregnancy or first trimester body mass index with neurodevelopmental impairment or death in extremely low gestational age neonates. Journal of Perinatology, 44(6), 802-810. https://doi.org/10.1038/s41372-024-01905-7

Chawla, S, Laptook, AR, Smith, EA, Tan, S, Natarajan, G, Wyckoff, MH, Greenberg, RG, Ambalavanan, N, Bell, EF, Van Meurs, KP, Hintz, SR, Vohr, BR, Werner, EF, Das, A, Shankaran, S, Carlo, WA, Hibbs, AM, Merhar, S, Cotten, CM, Patel, RM, Colaizy, TT, Hamvas, A, Bhatt, AJ, Fuller, J, DeMauro, S, Katheria, AC, Ohls, RK & Tyson, JE 2024, 'Association of maternal pre-pregnancy or first trimester body mass index with neurodevelopmental impairment or death in extremely low gestational age neonates', Journal of Perinatology, vol. 44, no. 6, pp. 802-810. https://doi.org/10.1038/s41372-024-01905-7

@article{8126be7e2d6a4c85b2db0cc1eb37f294,

title = "Association of maternal pre-pregnancy or first trimester body mass index with neurodevelopmental impairment or death in extremely low gestational age neonates",

abstract = "Objective: To compare the rates of death or survival with severe neurodevelopmental impairment (sNDI) at 2 years among extremely preterm infants in relation to pre-pregnancy or first-trimester maternal body mass index (BMI). Methods: This retrospective cohort study included extremely preterm infants (gestational age 220/7–266/7 weeks). The study was conducted at National Institute of Child Health and Human Development Neonatal Research Network sites. The primary outcome was death or sNDI at 2 years. Results: Data on the primary outcome were available for 1208 children. Death or sNDI was not different among the three groups: 54.9% in normal, 56.1% in overweight, and 53.4% in obese group (p = 0.39). There was no significant difference in mortality, sNDI, moderate/severe cerebral palsy, Bayley Scales of Infant Development (BSID)-III cognitive composite score <70, BSID-III language composite score <70 in adjusted models. Conclusion: Neurodevelopmental outcome was not significantly associated with maternal pre-pregnancy BMI among extreme preterm infants.",

author = "Sanjay Chawla and Laptook, {Abbot R.} and Smith, {Emily A.} and Sylvia Tan and Girija Natarajan and Wyckoff, {Myra H.} and Greenberg, {Rachel G.} and Namasivayam Ambalavanan and Bell, {Edward F.} and {Van Meurs}, {Krisa P.} and Hintz, {Susan R.} and Vohr, {Betty R.} and Werner, {Erika F.} and Abhik Das and Seetha Shankaran and Carlo, {Waldemar A.} and Hibbs, {Anna Maria} and Stephanie Merhar and Cotten, {C. Michael} and Patel, {Ravi M.} and Colaizy, {Tarah T.} and Aaron Hamvas and Bhatt, {Abhay J.} and Janell Fuller and Sara DeMauro and Katheria, {Anup C.} and Ohls, {Robin K.} and Tyson, {Jon E.}",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive licence to Springer Nature America, Inc. 2024.",

year = "2024",

month = jun,

doi = "10.1038/s41372-024-01905-7",

language = "English (US)",

volume = "44",

pages = "802--810",

journal = "Journal of Perinatology",

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TY - JOUR

T1 - Association of maternal pre-pregnancy or first trimester body mass index with neurodevelopmental impairment or death in extremely low gestational age neonates

AU - Chawla, Sanjay

AU - Laptook, Abbot R.

AU - Smith, Emily A.

AU - Tan, Sylvia

AU - Natarajan, Girija

AU - Wyckoff, Myra H.

AU - Greenberg, Rachel G.

AU - Ambalavanan, Namasivayam

AU - Bell, Edward F.

AU - Van Meurs, Krisa P.

AU - Hintz, Susan R.

AU - Vohr, Betty R.

AU - Werner, Erika F.

AU - Das, Abhik

AU - Shankaran, Seetha

AU - Carlo, Waldemar A.

AU - Hibbs, Anna Maria

AU - Merhar, Stephanie

AU - Cotten, C. Michael

AU - Patel, Ravi M.

AU - Colaizy, Tarah T.

AU - Hamvas, Aaron

AU - Bhatt, Abhay J.

AU - Fuller, Janell

AU - DeMauro, Sara

AU - Katheria, Anup C.

AU - Ohls, Robin K.

AU - Tyson, Jon E.

PY - 2024/6

Y1 - 2024/6

N2 - Objective: To compare the rates of death or survival with severe neurodevelopmental impairment (sNDI) at 2 years among extremely preterm infants in relation to pre-pregnancy or first-trimester maternal body mass index (BMI). Methods: This retrospective cohort study included extremely preterm infants (gestational age 220/7–266/7 weeks). The study was conducted at National Institute of Child Health and Human Development Neonatal Research Network sites. The primary outcome was death or sNDI at 2 years. Results: Data on the primary outcome were available for 1208 children. Death or sNDI was not different among the three groups: 54.9% in normal, 56.1% in overweight, and 53.4% in obese group (p = 0.39). There was no significant difference in mortality, sNDI, moderate/severe cerebral palsy, Bayley Scales of Infant Development (BSID)-III cognitive composite score <70, BSID-III language composite score <70 in adjusted models. Conclusion: Neurodevelopmental outcome was not significantly associated with maternal pre-pregnancy BMI among extreme preterm infants.

AB - Objective: To compare the rates of death or survival with severe neurodevelopmental impairment (sNDI) at 2 years among extremely preterm infants in relation to pre-pregnancy or first-trimester maternal body mass index (BMI). Methods: This retrospective cohort study included extremely preterm infants (gestational age 220/7–266/7 weeks). The study was conducted at National Institute of Child Health and Human Development Neonatal Research Network sites. The primary outcome was death or sNDI at 2 years. Results: Data on the primary outcome were available for 1208 children. Death or sNDI was not different among the three groups: 54.9% in normal, 56.1% in overweight, and 53.4% in obese group (p = 0.39). There was no significant difference in mortality, sNDI, moderate/severe cerebral palsy, Bayley Scales of Infant Development (BSID)-III cognitive composite score <70, BSID-III language composite score <70 in adjusted models. Conclusion: Neurodevelopmental outcome was not significantly associated with maternal pre-pregnancy BMI among extreme preterm infants.

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ER -

Association of maternal pre-pregnancy or first trimester body mass index with neurodevelopmental impairment or death in extremely low gestational age neonates

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