TY - JOUR
T1 - Association of antenatal steroids with surfactant administration in moderate preterm infants born to women with diabetes mellitus and/or hypertension
AU - Weydig, Heather M.
AU - Rosenfeld, Charles R.
AU - Wyckoff, Myra H.
AU - Jaleel, Mambarambath A.
AU - Burchfield, Patti J.
AU - Thomas, Anita
AU - Frost, Mackenzie S
AU - Brion, Luc P.
N1 - Funding Information:
We thank Dr. Bloom, Dr. Leveno, Dr. McIntire, Dr. Pérez-Fontán and Dr. Savani for participating in the discussions that eventually led to expansion of ANS to mothers with DM and GHTN on 9/21/2015. HMW, LPB and CRR conceptualized and designed the study. PJB, AT and LPB collected data. LPB carried out statistical analyses. HMW and LPB drafted the initial manuscript. All authors have revised the manuscript and approved the final manuscript as submitted and agree to be accountable for all aspects of the work.
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2022/8
Y1 - 2022/8
N2 - Background: Randomized trials of antenatal steroid administration (ANS) for extreme or moderate preterm pregnancies excluded women with diabetes mellitus (DM) and included few with preeclampsia. Methods: Cohort study (n = 1,813) including moderate preterm births [290/7–336/7wks’ gestational age GA)] before (Epoch-1) and after (Epoch-2) expansion of ANS administration to women with hypertensive disorders (HTN) and/or DM. We compared surfactant administration in Group-1 (neither HTN nor DM), Group-2a (HTN not DM), Group-2b (DM not HTN) and Group-2c (DM and HTN). Results: Surfactant administration was less frequent after ANS in Group-1 [adjusted odds ratio (aOR) 0.54, 95% confidence interval (CI) 0.31, 0.93, P = 0.03], Group-2a (aOR 0.36, CI 0.22, 0.58, P < 0.001) and Group-2c (aOR 0.29, CI 0.12, 0.71, P = 0.007) but not Group-2b (P = 0.64). Conclusions: ANS administration was independently associated with less surfactant administration in moderately preterm neonates whose mothers had neither HTN nor DM, and those with HTN, but not those with DM without HTN.
AB - Background: Randomized trials of antenatal steroid administration (ANS) for extreme or moderate preterm pregnancies excluded women with diabetes mellitus (DM) and included few with preeclampsia. Methods: Cohort study (n = 1,813) including moderate preterm births [290/7–336/7wks’ gestational age GA)] before (Epoch-1) and after (Epoch-2) expansion of ANS administration to women with hypertensive disorders (HTN) and/or DM. We compared surfactant administration in Group-1 (neither HTN nor DM), Group-2a (HTN not DM), Group-2b (DM not HTN) and Group-2c (DM and HTN). Results: Surfactant administration was less frequent after ANS in Group-1 [adjusted odds ratio (aOR) 0.54, 95% confidence interval (CI) 0.31, 0.93, P = 0.03], Group-2a (aOR 0.36, CI 0.22, 0.58, P < 0.001) and Group-2c (aOR 0.29, CI 0.12, 0.71, P = 0.007) but not Group-2b (P = 0.64). Conclusions: ANS administration was independently associated with less surfactant administration in moderately preterm neonates whose mothers had neither HTN nor DM, and those with HTN, but not those with DM without HTN.
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U2 - 10.1038/s41372-021-01273-6
DO - 10.1038/s41372-021-01273-6
M3 - Article
C2 - 34802046
AN - SCOPUS:85119446351
SN - 0743-8346
VL - 42
SP - 993
EP - 1000
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 8
ER -