Abstract
Aims: Obesity is a risk factor for an acute coronary syndrome (ACS). The association between elevated body mass index (BMI) and ACS is independent of most traditional risk factors, suggesting a possible contribution of other body fat-related mediators. This study evaluated the association between adiponectin and ACS. Methods and results: Four hundred and ninety-nine patients undergoing coronary angiography were divided into a subgroup without (n = 331) and with ACS (n = 168). In multiple regression analysis, higher adiponectin levels were independently associated with a lower risk of ACS [odds ratio (OR) = 0.61; 95% CIs: 0.46-0.81; P < 0.001]. In contrast, a higher BMI, a history of myocardial infarction, C-reactive protein, and angiographic coronary artery disease severity were all associated with a higher risk. The greatest increase in risk for ACS was seen at adiponectin levels ≤ 5.5 μg/mL. Conclusion: Higher plasma adiponectin levels are independently associated with a lower risk of ACS.
Original language | English (US) |
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Pages (from-to) | 292-298 |
Number of pages | 7 |
Journal | European heart journal |
Volume | 28 |
Issue number | 3 |
DOIs | |
State | Published - Feb 2007 |
Keywords
- Acute coronary syndrome
- Adipokines
- Adiponectin
- Angiography
- Atherosclerosis
- C-reactive protein
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine