Association between lung function and airway wall density

J. Ken Leader; Bin Zheng; Carl R. Fuhrman; John Tedrow; Sang C. Park; Jun Tan; Jiantao Pu; John M. Drescher; David Gur; Frank C. Sciurba

doi:10.1117/12.811768

Association between lung function and airway wall density

J. Ken Leader, Bin Zheng, Carl R. Fuhrman, John Tedrow, Sang C. Park, Jun Tan, Jiantao Pu, John M. Drescher, David Gur, Frank C. Sciurba

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

Computed tomography (CT) examination is often used to quantify the relation between lung function and airway remodeling in chronic obstructive pulmonary disease (COPD). In this preliminary study, we examined the association between lung function and airway wall computed attenuation ("density") in 200 COPD screening subjects. Percent predicted FVC (FVC%), percent predicted FEV1 (FEV1%), and the ratio of FEV1 to FVC as a percentage (FEV1/FVC%) were measured post-bronchodilator. The apical bronchus of the right upper lobe was manually selected from CT examinations for evaluation. Total airway area, lumen area, wall area, lumen perimeter and wall area as fraction of the total airway area were computed. Mean HU (meanHU) and maximum HU (maxHU) values were computed across pixels assigned membership in the wall and with a HU value greater than -550. The Pearson correlation coefficients (PCC) between FVC%, FEV1%, and FEV1/FVC% and meanHU were -0.221 (p = 0.002), -0.175 (p = 0.014), and -0.110 (p = 0.123), respectively. The PCCs for maxHU were only significant for FVC%. The correlations between lung function and the airway morphometry parameters were slightly stronger compared to airway wall density. MeanHU was significantly correlated with wall area (PCC = 0.720), airway area (0.498) and wall area percent (0.611). This preliminary work demonstrates that airway wall density is associated with lung function. Although the correlations in our study were weaker than a recent study, airway wall density initially appears to be an important parameter in quantitative CT analysis of COPD.

Original language	English (US)
Title of host publication	Medical Imaging 2009
Subtitle of host publication	Biomedical Applications in Molecular, Structural, and Functional Imaging
DOIs	https://doi.org/10.1117/12.811768
State	Published - 2009
Event	Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging - Lake Buena Vista, FL, United States Duration: Feb 8 2009 → Feb 10 2009

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	7262
ISSN (Print)	1605-7422

Other

Other	Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging
Country/Territory	United States
City	Lake Buena Vista, FL
Period	2/8/09 → 2/10/09

Keywords

Airway
Airway morphometry
Airway remodeling
COPD
lung function

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging
Biomaterials

Access to Document

10.1117/12.811768

Cite this

Leader, J. K., Zheng, B., Fuhrman, C. R., Tedrow, J., Park, S. C., Tan, J., Pu, J., Drescher, J. M., Gur, D., & Sciurba, F. C. (2009). Association between lung function and airway wall density. In Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging Article 72622J (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7262). https://doi.org/10.1117/12.811768

Association between lung function and airway wall density. / Leader, J. Ken; Zheng, Bin; Fuhrman, Carl R. et al.
Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging. 2009. 72622J (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7262).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Leader, JK, Zheng, B, Fuhrman, CR, Tedrow, J, Park, SC, Tan, J, Pu, J, Drescher, JM, Gur, D & Sciurba, FC 2009, Association between lung function and airway wall density. in Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging., 72622J, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 7262, Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging, Lake Buena Vista, FL, United States, 2/8/09. https://doi.org/10.1117/12.811768

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title = "Association between lung function and airway wall density",

abstract = "Computed tomography (CT) examination is often used to quantify the relation between lung function and airway remodeling in chronic obstructive pulmonary disease (COPD). In this preliminary study, we examined the association between lung function and airway wall computed attenuation ({"}density{"}) in 200 COPD screening subjects. Percent predicted FVC (FVC%), percent predicted FEV1 (FEV1%), and the ratio of FEV1 to FVC as a percentage (FEV1/FVC%) were measured post-bronchodilator. The apical bronchus of the right upper lobe was manually selected from CT examinations for evaluation. Total airway area, lumen area, wall area, lumen perimeter and wall area as fraction of the total airway area were computed. Mean HU (meanHU) and maximum HU (maxHU) values were computed across pixels assigned membership in the wall and with a HU value greater than -550. The Pearson correlation coefficients (PCC) between FVC%, FEV1%, and FEV1/FVC% and meanHU were -0.221 (p = 0.002), -0.175 (p = 0.014), and -0.110 (p = 0.123), respectively. The PCCs for maxHU were only significant for FVC%. The correlations between lung function and the airway morphometry parameters were slightly stronger compared to airway wall density. MeanHU was significantly correlated with wall area (PCC = 0.720), airway area (0.498) and wall area percent (0.611). This preliminary work demonstrates that airway wall density is associated with lung function. Although the correlations in our study were weaker than a recent study, airway wall density initially appears to be an important parameter in quantitative CT analysis of COPD.",

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author = "Leader, {J. Ken} and Bin Zheng and Fuhrman, {Carl R.} and John Tedrow and Park, {Sang C.} and Jun Tan and Jiantao Pu and Drescher, {John M.} and David Gur and Sciurba, {Frank C.}",

note = "Copyright: Copyright 2009 Elsevier B.V., All rights reserved.; Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging ; Conference date: 08-02-2009 Through 10-02-2009",

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AU - Pu, Jiantao

AU - Drescher, John M.

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N2 - Computed tomography (CT) examination is often used to quantify the relation between lung function and airway remodeling in chronic obstructive pulmonary disease (COPD). In this preliminary study, we examined the association between lung function and airway wall computed attenuation ("density") in 200 COPD screening subjects. Percent predicted FVC (FVC%), percent predicted FEV1 (FEV1%), and the ratio of FEV1 to FVC as a percentage (FEV1/FVC%) were measured post-bronchodilator. The apical bronchus of the right upper lobe was manually selected from CT examinations for evaluation. Total airway area, lumen area, wall area, lumen perimeter and wall area as fraction of the total airway area were computed. Mean HU (meanHU) and maximum HU (maxHU) values were computed across pixels assigned membership in the wall and with a HU value greater than -550. The Pearson correlation coefficients (PCC) between FVC%, FEV1%, and FEV1/FVC% and meanHU were -0.221 (p = 0.002), -0.175 (p = 0.014), and -0.110 (p = 0.123), respectively. The PCCs for maxHU were only significant for FVC%. The correlations between lung function and the airway morphometry parameters were slightly stronger compared to airway wall density. MeanHU was significantly correlated with wall area (PCC = 0.720), airway area (0.498) and wall area percent (0.611). This preliminary work demonstrates that airway wall density is associated with lung function. Although the correlations in our study were weaker than a recent study, airway wall density initially appears to be an important parameter in quantitative CT analysis of COPD.

AB - Computed tomography (CT) examination is often used to quantify the relation between lung function and airway remodeling in chronic obstructive pulmonary disease (COPD). In this preliminary study, we examined the association between lung function and airway wall computed attenuation ("density") in 200 COPD screening subjects. Percent predicted FVC (FVC%), percent predicted FEV1 (FEV1%), and the ratio of FEV1 to FVC as a percentage (FEV1/FVC%) were measured post-bronchodilator. The apical bronchus of the right upper lobe was manually selected from CT examinations for evaluation. Total airway area, lumen area, wall area, lumen perimeter and wall area as fraction of the total airway area were computed. Mean HU (meanHU) and maximum HU (maxHU) values were computed across pixels assigned membership in the wall and with a HU value greater than -550. The Pearson correlation coefficients (PCC) between FVC%, FEV1%, and FEV1/FVC% and meanHU were -0.221 (p = 0.002), -0.175 (p = 0.014), and -0.110 (p = 0.123), respectively. The PCCs for maxHU were only significant for FVC%. The correlations between lung function and the airway morphometry parameters were slightly stronger compared to airway wall density. MeanHU was significantly correlated with wall area (PCC = 0.720), airway area (0.498) and wall area percent (0.611). This preliminary work demonstrates that airway wall density is associated with lung function. Although the correlations in our study were weaker than a recent study, airway wall density initially appears to be an important parameter in quantitative CT analysis of COPD.

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ER -

Association between lung function and airway wall density

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Keywords

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