Assessment of SS-A SS-B in parotid saliva of patients with Sjögren's syndrome

Ann Rose Hammi, Ibtisam H. Al-Hashimi, Martha E. Nunn, Michele Zipp

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


BACKGROUND: The purpose of this study was to compare the sensitivity of parotid saliva to that of serum in detecting anti-SSA/Ro and anti-SSB/La autoantibodies in patients with Sjögren's syndrome. METHODS: Forty patients and 20 controls participated in the study; all patients met the 1993 European Community criteria for the diagnosis of Sjögren's syndrome. Healthy controls were age- and sex-matched individuals with no signs or symptoms of Sjögren's syndrome. Serum and saliva samples were evaluated using AffiniTech SSA/ Ro and SSB/La antibodies kits (AffiniTech, Ltd. Bentonville, AR, USA). The results were also compared with serological status of SS-A and SS-B as reported by an independent clinical laboratory. RESULTS: Serum was significantly more sensitive than saliva in detecting SSA/Ro and SSB/La antibodies (P = 0.001). There was high agreement between the results with the AffiniTech kits and the independent laboratory (kappa = 0.80; P < 0.001). However, there was poor agreement between saliva and serum results (kappa = 0.174; P = 0.168). CONCLUSIONS: The overall results appear to support that serum analysis is effective method for evaluating the presence of SS-A and SS-B autoantibodies.

Original languageEnglish (US)
Pages (from-to)198-203
Number of pages6
JournalJournal of Oral Pathology and Medicine
Issue number4
StatePublished - Apr 1 2005


  • Autoantibodies
  • Diagnosis
  • SS-A
  • SS-B
  • Saliva
  • Sjögren's syndrome

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics


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