TY - JOUR
T1 - Assessment of disease activity in large-vessel vasculitis
T2 - Results of an international delphi exercise
AU - International Delphi on Disease Activity Assessment in Large-vessel Vasculitis
AU - Aydin, Sibel Z.
AU - Direskeneli, Haner
AU - Merkel, Peter A.
AU - Toloza, Sergio
AU - Blockmans, Daniel
AU - Sato, Emilia Inoue
AU - De Souza, Alexandre Wagner Silva
AU - Cabral, David
AU - Carette, Simon
AU - Famorca, Leilani
AU - Khalidi, Nader
AU - Milman, Nataliya
AU - Yacyshyn, Elaine
AU - Tesar, Vladimir
AU - Baslund, Bo
AU - Faurschou, Mikkel
AU - Guillevin, Loïc
AU - Puéchal, Xavier
AU - Aries, Peer
AU - Hellmich, Bernhard
AU - Herlyn, Karen
AU - Holle, Julia
AU - Lamprecht, Peter
AU - Moosig, Frank
AU - Neumann, Thomas
AU - Zwerina, Jochen
AU - Tómasson, Gunnar
AU - Bambery, Pradeep
AU - Jois, Ramesh
AU - Rajasekhar, Liza
AU - Sharma, Aman
AU - Sivakumar, Rajappa
AU - Molloy, Eamonn
AU - Hashkes, Philip
AU - Catapano, Fausta
AU - Cimino, Luca
AU - De Fanti, Alessandro
AU - Pipitone, Nicolo
AU - Salvarani, Carlo
AU - Vaglio, Augusto
AU - Kobayashi, Shigeto
AU - Suzuki, Kazuo
AU - Flores-Suárez, Luis Felipe
AU - Hinojosa-Azaola, Andrea
AU - Brouwer, Elisabeth
AU - Rutgers, Abraham
AU - Stegeman, Coen
AU - Suppiah, Ravi
AU - Hollan, Ivana
AU - Beckman, Joshua
N1 - Publisher Copyright:
Copyright © 2017. All rights reserved.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Objective. To arrive at consensus for candidate outcomes for disease activity assessment in largevessel vasculitis (LVV) in clinical trials. Methods.A Delphi survey including 99 items was circulated among international experts for 3 rounds. Results. Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging. Conclusion. This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes.
AB - Objective. To arrive at consensus for candidate outcomes for disease activity assessment in largevessel vasculitis (LVV) in clinical trials. Methods.A Delphi survey including 99 items was circulated among international experts for 3 rounds. Results. Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging. Conclusion. This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes.
KW - Giant cell arteritis
KW - Large vessel
KW - Outcomes
KW - Takayasu arteritis
KW - Vasculitis
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UR - http://www.scopus.com/inward/citedby.url?scp=85037094161&partnerID=8YFLogxK
U2 - 10.3899/jrheum.161269
DO - 10.3899/jrheum.161269
M3 - Article
C2 - 28864648
AN - SCOPUS:85037094161
SN - 0315-162X
VL - 44
SP - 1928
EP - 1932
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 12
ER -