Assessment of coronary heart disease risk by combined analysis of coagulation factors

Nena Aleksic; Yao Wei W Wang; Chul Ahn; Harinder S. Juneja; Aaron R. Folsom; Kenneth K. Wu

doi:10.1016/j.atherosclerosis.2007.12.062

Assessment of coronary heart disease risk by combined analysis of coagulation factors

Nena Aleksic, Yao Wei W Wang, Chul Ahn, Harinder S. Juneja, Aaron R. Folsom, Kenneth K. Wu

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Objective: Prospective studies have reported a positive association of coagulation factors with risk of coronary heart disease (CHD). It is unclear whether these coagulation factors interact. Methods and results: Using a prospective case-cohort design, we analyzed by Cox proportional hazard regression interactions between soluble thrombomodulin (sTM) and fibrinogen, factor VIII (FVIII), FVII, or plasminogen activator inhibitor-1 (PAI-1) in 410 CHD cases and 721 non-cases from the Atherosclerosis Risk in Communities (ARIC). There was a significant interaction between sTM and fibrinogen (p = 0.027). We next assessed risk ratios (RR) by combined tertile analysis. Combined analysis revealed that being in the upper sTM tertile counteracted the CHD risk imposed by higher fibrinogen whereas being in the lower sTM tertile amplified the CHD risk of higher fibrinogen. sTM and fibrinogen mutually influenced CHD incidence in a concentration-dependent manner. When analyzed as single factors by tertiles, FVIII, FVII and PAI-1 were not associated with CHD. However, when analyzed together with sTM, FVIII and PAI-1 were both positively associated with CHD for those in the lower sTM tertile. Conclusion: There is a complex interaction between sTM and prothrombotic coagulation factors. Combined analysis improves CHD risk assessment.

Original language	English (US)
Pages (from-to)	294-300
Number of pages	7
Journal	Atherosclerosis
Volume	198
Issue number	2
DOIs	https://doi.org/10.1016/j.atherosclerosis.2007.12.062
State	Published - Jun 2008

Keywords

Coronary heart disease
Factor VIII
Fibrinogen
PAI-1
Soluble thrombomodulin

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.atherosclerosis.2007.12.062

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@article{f1483e64c363421b9ad7313545cb309b,

title = "Assessment of coronary heart disease risk by combined analysis of coagulation factors",

abstract = "Objective: Prospective studies have reported a positive association of coagulation factors with risk of coronary heart disease (CHD). It is unclear whether these coagulation factors interact. Methods and results: Using a prospective case-cohort design, we analyzed by Cox proportional hazard regression interactions between soluble thrombomodulin (sTM) and fibrinogen, factor VIII (FVIII), FVII, or plasminogen activator inhibitor-1 (PAI-1) in 410 CHD cases and 721 non-cases from the Atherosclerosis Risk in Communities (ARIC). There was a significant interaction between sTM and fibrinogen (p = 0.027). We next assessed risk ratios (RR) by combined tertile analysis. Combined analysis revealed that being in the upper sTM tertile counteracted the CHD risk imposed by higher fibrinogen whereas being in the lower sTM tertile amplified the CHD risk of higher fibrinogen. sTM and fibrinogen mutually influenced CHD incidence in a concentration-dependent manner. When analyzed as single factors by tertiles, FVIII, FVII and PAI-1 were not associated with CHD. However, when analyzed together with sTM, FVIII and PAI-1 were both positively associated with CHD for those in the lower sTM tertile. Conclusion: There is a complex interaction between sTM and prothrombotic coagulation factors. Combined analysis improves CHD risk assessment.",

keywords = "Coronary heart disease, Factor VIII, Fibrinogen, PAI-1, Soluble thrombomodulin",

author = "Nena Aleksic and Wang, {Yao Wei W} and Chul Ahn and Juneja, {Harinder S.} and Folsom, {Aaron R.} and Wu, {Kenneth K.}",

note = "Funding Information: The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021 and N01-HC-55022. The authors thank the staff and participants of the ARIC study for their important contributions. We thank Ms. Susan Mitterling for preparing this manuscript and editorial assistance. ",

year = "2008",

month = jun,

doi = "10.1016/j.atherosclerosis.2007.12.062",

language = "English (US)",

volume = "198",

pages = "294--300",

journal = "Atherosclerosis",

issn = "0021-9150",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Assessment of coronary heart disease risk by combined analysis of coagulation factors

AU - Aleksic, Nena

AU - Wang, Yao Wei W

AU - Ahn, Chul

AU - Juneja, Harinder S.

AU - Folsom, Aaron R.

AU - Wu, Kenneth K.

N1 - Funding Information: The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021 and N01-HC-55022. The authors thank the staff and participants of the ARIC study for their important contributions. We thank Ms. Susan Mitterling for preparing this manuscript and editorial assistance.

PY - 2008/6

Y1 - 2008/6

N2 - Objective: Prospective studies have reported a positive association of coagulation factors with risk of coronary heart disease (CHD). It is unclear whether these coagulation factors interact. Methods and results: Using a prospective case-cohort design, we analyzed by Cox proportional hazard regression interactions between soluble thrombomodulin (sTM) and fibrinogen, factor VIII (FVIII), FVII, or plasminogen activator inhibitor-1 (PAI-1) in 410 CHD cases and 721 non-cases from the Atherosclerosis Risk in Communities (ARIC). There was a significant interaction between sTM and fibrinogen (p = 0.027). We next assessed risk ratios (RR) by combined tertile analysis. Combined analysis revealed that being in the upper sTM tertile counteracted the CHD risk imposed by higher fibrinogen whereas being in the lower sTM tertile amplified the CHD risk of higher fibrinogen. sTM and fibrinogen mutually influenced CHD incidence in a concentration-dependent manner. When analyzed as single factors by tertiles, FVIII, FVII and PAI-1 were not associated with CHD. However, when analyzed together with sTM, FVIII and PAI-1 were both positively associated with CHD for those in the lower sTM tertile. Conclusion: There is a complex interaction between sTM and prothrombotic coagulation factors. Combined analysis improves CHD risk assessment.

AB - Objective: Prospective studies have reported a positive association of coagulation factors with risk of coronary heart disease (CHD). It is unclear whether these coagulation factors interact. Methods and results: Using a prospective case-cohort design, we analyzed by Cox proportional hazard regression interactions between soluble thrombomodulin (sTM) and fibrinogen, factor VIII (FVIII), FVII, or plasminogen activator inhibitor-1 (PAI-1) in 410 CHD cases and 721 non-cases from the Atherosclerosis Risk in Communities (ARIC). There was a significant interaction between sTM and fibrinogen (p = 0.027). We next assessed risk ratios (RR) by combined tertile analysis. Combined analysis revealed that being in the upper sTM tertile counteracted the CHD risk imposed by higher fibrinogen whereas being in the lower sTM tertile amplified the CHD risk of higher fibrinogen. sTM and fibrinogen mutually influenced CHD incidence in a concentration-dependent manner. When analyzed as single factors by tertiles, FVIII, FVII and PAI-1 were not associated with CHD. However, when analyzed together with sTM, FVIII and PAI-1 were both positively associated with CHD for those in the lower sTM tertile. Conclusion: There is a complex interaction between sTM and prothrombotic coagulation factors. Combined analysis improves CHD risk assessment.

KW - Coronary heart disease

KW - Factor VIII

KW - Fibrinogen

KW - PAI-1

KW - Soluble thrombomodulin

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U2 - 10.1016/j.atherosclerosis.2007.12.062

DO - 10.1016/j.atherosclerosis.2007.12.062

M3 - Article

C2 - 18342864

AN - SCOPUS:44149116748

SN - 0021-9150

VL - 198

SP - 294

EP - 300

JO - Atherosclerosis

JF - Atherosclerosis

IS - 2

ER -

Assessment of coronary heart disease risk by combined analysis of coagulation factors

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