Arrhythmias in Cardiac Sarcoidosis Bench to Bedside: A Case-Based Review

Lynda E. Rosenfeld; Mina K. Chung; Clifford V. Harding; Paolo Spagnolo; Johan Grunewald; Jason Appelbaum; William H. Sauer; Daniel A. Culver; Jose A. Joglar; Ben A. Lin; Christine L. Jellis; Timm Michael Dickfeld; Deborah H. Kwon; Edward J. Miller; Paul C. Cremer; Frank Bogun; Jordana Kron; Ashley Bock; Davendra Mehta; Paul Leis; Konstantinos C. Siontis; Elizabeth S. Kaufman; Thomas Crawford; Peter Zimetbaum; Edwin T. Zishiri; Jagmeet P. Singh; Kenneth A. Ellenbogen; Jonathan Chrispin; Syed Quadri; Logan L. Vincent; Kristen K. Patton; Steven Kalbfleish; Thomas D. Callahan; Francis Murgatroyd; Marc A. Judson; David Birnie; David R. Okada; Christopher Maulion; Pavan Bhat; Lavanya Bellumkonda; Ron Blankstein; Richard K. Cheng; Maryjane A. Farr; Jerry D. Estep

doi:10.1161/CIRCEP.120.009203

Arrhythmias in Cardiac Sarcoidosis Bench to Bedside: A Case-Based Review

Lynda E. Rosenfeld, Mina K. Chung, Clifford V. Harding, Paolo Spagnolo, Johan Grunewald, Jason Appelbaum, William H. Sauer, Daniel A. Culver, Jose A. Joglar, Ben A. Lin, Christine L. Jellis, Timm Michael Dickfeld, Deborah H. Kwon, Edward J. Miller, Paul C. Cremer, Frank Bogun, Jordana Kron, Ashley Bock, Davendra Mehta, Paul LeisKonstantinos C. Siontis, Elizabeth S. Kaufman, Thomas Crawford, Peter Zimetbaum, Edwin T. Zishiri, Jagmeet P. Singh, Kenneth A. Ellenbogen, Jonathan Chrispin, Syed Quadri, Logan L. Vincent, Kristen K. Patton, Steven Kalbfleish, Thomas D. Callahan, Francis Murgatroyd, Marc A. Judson, David Birnie, David R. Okada, Christopher Maulion, Pavan Bhat, Lavanya Bellumkonda, Ron Blankstein, Richard K. Cheng, Maryjane A. Farr, Jerry D. Estep

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Cardiac sarcoidosis is a component of an often multiorgan granulomatous disease of still uncertain cause. It is being recognized with increasing frequency, mainly as the result of heightened awareness and new diagnostic tests, specifically cardiac magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography scans. The purpose of this case-based review is to highlight the potentially life-saving importance of making the early diagnosis of cardiac sarcoidosis using these new tools and to provide a framework for the optimal care of patients with this disease. We will review disease mechanisms as currently understood, associated arrhythmias including conduction abnormalities, and atrial and ventricular tachyarrhythmias, guideline-directed diagnostic criteria, screening of patients with extracardiac sarcoidosis, and the use of pacemakers and defibrillators in this setting. Treatment options, including those related to heart failure, and those which may help clarify disease mechanisms are included.

Original language	English (US)
Pages (from-to)	E009203
Journal	Circulation: Arrhythmia and Electrophysiology
Volume	14
Issue number	2
DOIs	https://doi.org/10.1161/CIRCEP.120.009203
State	Published - Feb 1 2021

Keywords

Atrial fibrillation
Bradycardia
Defibrillator
Heart failure
Sarcoidosis
Tachycardia

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1161/CIRCEP.120.009203

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Rosenfeld, L. E., Chung, M. K., Harding, C. V., Spagnolo, P., Grunewald, J., Appelbaum, J., Sauer, W. H., Culver, D. A., Joglar, J. A., Lin, B. A., Jellis, C. L., Dickfeld, T. M., Kwon, D. H., Miller, E. J., Cremer, P. C., Bogun, F., Kron, J., Bock, A., Mehta, D., ... Estep, J. D. (2021). Arrhythmias in Cardiac Sarcoidosis Bench to Bedside: A Case-Based Review. Circulation: Arrhythmia and Electrophysiology, 14(2), E009203. https://doi.org/10.1161/CIRCEP.120.009203

Rosenfeld, LE, Chung, MK, Harding, CV, Spagnolo, P, Grunewald, J, Appelbaum, J, Sauer, WH, Culver, DA, Joglar, JA, Lin, BA, Jellis, CL, Dickfeld, TM, Kwon, DH, Miller, EJ, Cremer, PC, Bogun, F, Kron, J, Bock, A, Mehta, D, Leis, P, Siontis, KC, Kaufman, ES, Crawford, T, Zimetbaum, P, Zishiri, ET, Singh, JP, Ellenbogen, KA, Chrispin, J, Quadri, S, Vincent, LL, Patton, KK, Kalbfleish, S, Callahan, TD, Murgatroyd, F, Judson, MA, Birnie, D, Okada, DR, Maulion, C, Bhat, P, Bellumkonda, L, Blankstein, R, Cheng, RK, Farr, MA & Estep, JD 2021, 'Arrhythmias in Cardiac Sarcoidosis Bench to Bedside: A Case-Based Review', Circulation: Arrhythmia and Electrophysiology, vol. 14, no. 2, pp. E009203. https://doi.org/10.1161/CIRCEP.120.009203

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title = "Arrhythmias in Cardiac Sarcoidosis Bench to Bedside: A Case-Based Review",

abstract = "Cardiac sarcoidosis is a component of an often multiorgan granulomatous disease of still uncertain cause. It is being recognized with increasing frequency, mainly as the result of heightened awareness and new diagnostic tests, specifically cardiac magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography scans. The purpose of this case-based review is to highlight the potentially life-saving importance of making the early diagnosis of cardiac sarcoidosis using these new tools and to provide a framework for the optimal care of patients with this disease. We will review disease mechanisms as currently understood, associated arrhythmias including conduction abnormalities, and atrial and ventricular tachyarrhythmias, guideline-directed diagnostic criteria, screening of patients with extracardiac sarcoidosis, and the use of pacemakers and defibrillators in this setting. Treatment options, including those related to heart failure, and those which may help clarify disease mechanisms are included.",

keywords = "Atrial fibrillation, Bradycardia, Defibrillator, Heart failure, Sarcoidosis, Tachycardia",

author = "Rosenfeld, {Lynda E.} and Chung, {Mina K.} and Harding, {Clifford V.} and Paolo Spagnolo and Johan Grunewald and Jason Appelbaum and Sauer, {William H.} and Culver, {Daniel A.} and Joglar, {Jose A.} and Lin, {Ben A.} and Jellis, {Christine L.} and Dickfeld, {Timm Michael} and Kwon, {Deborah H.} and Miller, {Edward J.} and Cremer, {Paul C.} and Frank Bogun and Jordana Kron and Ashley Bock and Davendra Mehta and Paul Leis and Siontis, {Konstantinos C.} and Kaufman, {Elizabeth S.} and Thomas Crawford and Peter Zimetbaum and Zishiri, {Edwin T.} and Singh, {Jagmeet P.} and Ellenbogen, {Kenneth A.} and Jonathan Chrispin and Syed Quadri and Vincent, {Logan L.} and Patton, {Kristen K.} and Steven Kalbfleish and Callahan, {Thomas D.} and Francis Murgatroyd and Judson, {Marc A.} and David Birnie and Okada, {David R.} and Christopher Maulion and Pavan Bhat and Lavanya Bellumkonda and Ron Blankstein and Cheng, {Richard K.} and Farr, {Maryjane A.} and Estep, {Jerry D.}",

note = "Publisher Copyright: {\textcopyright} 2021 American Heart Association, Inc.",

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doi = "10.1161/CIRCEP.120.009203",

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T2 - A Case-Based Review

AU - Rosenfeld, Lynda E.

AU - Chung, Mina K.

AU - Harding, Clifford V.

AU - Spagnolo, Paolo

AU - Grunewald, Johan

AU - Appelbaum, Jason

AU - Sauer, William H.

AU - Culver, Daniel A.

AU - Joglar, Jose A.

AU - Lin, Ben A.

AU - Jellis, Christine L.

AU - Dickfeld, Timm Michael

AU - Kwon, Deborah H.

AU - Miller, Edward J.

AU - Cremer, Paul C.

AU - Bogun, Frank

AU - Kron, Jordana

AU - Bock, Ashley

AU - Mehta, Davendra

AU - Leis, Paul

AU - Siontis, Konstantinos C.

AU - Kaufman, Elizabeth S.

AU - Crawford, Thomas

AU - Zimetbaum, Peter

AU - Zishiri, Edwin T.

AU - Singh, Jagmeet P.

AU - Ellenbogen, Kenneth A.

AU - Chrispin, Jonathan

AU - Quadri, Syed

AU - Vincent, Logan L.

AU - Patton, Kristen K.

AU - Kalbfleish, Steven

AU - Callahan, Thomas D.

AU - Murgatroyd, Francis

AU - Judson, Marc A.

AU - Birnie, David

AU - Okada, David R.

AU - Maulion, Christopher

AU - Bhat, Pavan

AU - Bellumkonda, Lavanya

AU - Blankstein, Ron

AU - Cheng, Richard K.

AU - Farr, Maryjane A.

AU - Estep, Jerry D.

PY - 2021/2/1

Y1 - 2021/2/1

N2 - Cardiac sarcoidosis is a component of an often multiorgan granulomatous disease of still uncertain cause. It is being recognized with increasing frequency, mainly as the result of heightened awareness and new diagnostic tests, specifically cardiac magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography scans. The purpose of this case-based review is to highlight the potentially life-saving importance of making the early diagnosis of cardiac sarcoidosis using these new tools and to provide a framework for the optimal care of patients with this disease. We will review disease mechanisms as currently understood, associated arrhythmias including conduction abnormalities, and atrial and ventricular tachyarrhythmias, guideline-directed diagnostic criteria, screening of patients with extracardiac sarcoidosis, and the use of pacemakers and defibrillators in this setting. Treatment options, including those related to heart failure, and those which may help clarify disease mechanisms are included.

AB - Cardiac sarcoidosis is a component of an often multiorgan granulomatous disease of still uncertain cause. It is being recognized with increasing frequency, mainly as the result of heightened awareness and new diagnostic tests, specifically cardiac magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography scans. The purpose of this case-based review is to highlight the potentially life-saving importance of making the early diagnosis of cardiac sarcoidosis using these new tools and to provide a framework for the optimal care of patients with this disease. We will review disease mechanisms as currently understood, associated arrhythmias including conduction abnormalities, and atrial and ventricular tachyarrhythmias, guideline-directed diagnostic criteria, screening of patients with extracardiac sarcoidosis, and the use of pacemakers and defibrillators in this setting. Treatment options, including those related to heart failure, and those which may help clarify disease mechanisms are included.

KW - Atrial fibrillation

KW - Bradycardia

KW - Defibrillator

KW - Heart failure

KW - Sarcoidosis

KW - Tachycardia

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U2 - 10.1161/CIRCEP.120.009203

DO - 10.1161/CIRCEP.120.009203

M3 - Review article

C2 - 33591816

AN - SCOPUS:85101663563

SN - 1941-3149

VL - 14

SP - E009203

JO - Circulation: Arrhythmia and Electrophysiology

JF - Circulation: Arrhythmia and Electrophysiology

IS - 2

ER -

Arrhythmias in Cardiac Sarcoidosis Bench to Bedside: A Case-Based Review

Abstract

Keywords

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