Abstract
Patients with type 2 diabetes often need higher doses of insulin because of obesity and decreased insulin sensitivity. Insulin sensitizing agents act as useful additions to insulin therapy to combat worsening insulin sensitivity. The biguanides and the thiazolidinediones act directly to improve insulin sensitivity, and so are regarded as insulin sensitizing drugs. Many people with type 2 diabetes are overweight and insulin-resistant, making high doses of insulin often necessary to achieve adequate glucose control. Women suffering from polycystic ovary syndrome have an increased risk of diabetes later in life, and an increased incidence of gestational diabetes if they conceive. Studies have shown that low-density lipoprotein cholesterol levels have remained unchanged when mono therapy with pioglitazone or combination therapy with pioglitazone and sulfonylurea, metformin, or insulin has been used. The most common form of lipodystrophy is that associated with highly active antiretroviral therapy use in patients with human immunodeficiency virus disease.
Original language | English (US) |
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Title of host publication | Clinical Dilemmas in Diabetes |
Subtitle of host publication | Second Edition |
Publisher | wiley |
Pages | 133-145 |
Number of pages | 13 |
ISBN (Electronic) | 9781119603207 |
ISBN (Print) | 9781119603160 |
DOIs | |
State | Published - Jan 1 2021 |
ASJC Scopus subject areas
- General Medicine