Architectural and Functional Commonalities between Enhancers and Promoters

Tae Kyung Kim; Ramin Shiekhattar

doi:10.1016/j.cell.2015.08.008

Architectural and Functional Commonalities between Enhancers and Promoters

Tae Kyung Kim, Ramin Shiekhattar

Research output: Contribution to journal › Review article › peer-review

222 Scopus citations

Abstract

With the explosion of genome-wide studies of regulated transcription, it has become clear that traditional definitions of enhancers and promoters need to be revisited. These control elements can now be characterized in terms of their local and regional architecture, their regulatory components, including histone modifications and associated binding factors, and their functional contribution to transcription. This Review discusses unifying themes between promoters and enhancers in transcriptional regulatory mechanisms.

Original language	English (US)
Pages (from-to)	948-959
Number of pages	12
Journal	Cell
Volume	162
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2015.08.008
State	Published - Aug 27 2015

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2015.08.008

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abstract = "With the explosion of genome-wide studies of regulated transcription, it has become clear that traditional definitions of enhancers and promoters need to be revisited. These control elements can now be characterized in terms of their local and regional architecture, their regulatory components, including histone modifications and associated binding factors, and their functional contribution to transcription. This Review discusses unifying themes between promoters and enhancers in transcriptional regulatory mechanisms.",

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Architectural and Functional Commonalities between Enhancers and Promoters

Abstract

ASJC Scopus subject areas

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