Arachidonic acid epoxygenase: detection of epoxyeicosatrienoic acids in human urine

Robert Toto, Arup Siddhanta, Sukumar Manna, Bikash Pramanik, J. R. Faick, Jorge Capdevila

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Epoxyeicosatrienoic acids, metabolites of the cytochrome P-450-mediated epoxygenase reaction, were detected in human urine by gas chromatographic-mass spectroscopic techniques after conversion to their hydrogenated and non-hydrogenated methyl and pentafluorobenzyl esters. Initial analysis of the regioisomeric composition utilizing the corresponding hydrogenated pentafluorobenzyl esters revealed the presence of the 8,9- and 14,15-isomers.

Original languageEnglish (US)
Pages (from-to)132-139
Number of pages8
JournalBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Issue number2
StatePublished - Jun 2 1987


  • (Human)
  • Arachidonic acid
  • Epoxygenase
  • Epoxyicosatrienoic acid
  • Urinary metabolite

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Endocrinology


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